三酰甘油葡萄糖指数变异性与新发高尿酸血症相关性的队列研究  

A cohort study of the correlation between triglyceride-glucose index variability and new-onset hyperuricemia

作　　者：贾秋越 陈静锋 王佑翔 王琳[2] 丁素英[1,2] Jia Qiuyue;Chen Jingfeng;Wang Youxiang;Wang Lin;Ding Suying(Epidemiology Program,Public Health College,Zhengzhou University,Zhengzhou 450001,China;Health Management Center,First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学公共卫生学院流行病学教研室,郑州450001 [2]郑州大学第一附属医院健康管理中心,郑州450052

出　　处：《中华内分泌代谢杂志》2025年第2期99-105,共7页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金(72101236);中国博士后科学基金(2022M722900);河南省科技攻关项目(242102311099)。

摘　　要：目的评估三酰甘油葡萄糖(TyG)指数水平及变异性与新发高尿酸血症(hyperuricemia,HUA)风险的相关性。方法选取在郑州市某三级医院体检中心接受随访且依从性良好者1583例,通过收集受试者连续3年健康体检的TyG指数值计算TyG指数平均值(TyG-mean)和变异性指标,包括标准差(TyG-SD)、变异系数(TyG-CV)以及调整后的标准差(adj-TyG-SD)。采用Cox比例风险回归模型评估TyG指数变异性与新发HUA风险的关系;采用限制性立方样条(restricted cubic spline,RCS)检验不同TyG指数与HUA的剂量反应关系。结果3年随访期结束,共146例受检者新发HUA,HUA组的TyG-mean及TyG指数变异性指标均高于正常组(P<0.05)。Cox比例风险回归模型校正多种混杂因素后显示,TyG-SD、TyG-CV、adj-TyG-SD每增加一个标准差σ,HUA的发生风险分别增加1.23倍(95%CI 1.06~1.43)、1.22倍(95%CI 1.05~1.42)、1.26倍(95%CI 1.08~1.45)。RCS显示,adj-TyG-SD和HUA发生风险呈非线性相关(P<0.05),当HR为1时,其临界值为0.55。结论TyG指数变异性增加HUA发生风险,其中adj-TyG-SD与HUA发生风险相关性最高。Objective To evaluate the association between triglyceride-glucose(TyG)index level,their variability,and the risk of incident hyperuricemia(HUA).Methods A total of 1583 cases with good compliance who underwent follow-up at the health examination center of a tertiary hospital physical in Zhengzhou were enrolled.The TyG index mean(TyG-mean)and variability indexes,including standard deviation(TyG-SD),coefficient of variation(TyG-CV),and adjusted standard deviation(adj-TyG-SD),were calculated based on TyG index values from three consecutive annual health check-ups.Cox proportional risk regression model was used to assess the relationship between the variability of TyG index and the risk of new-onset HUA;the dose-response relationship between different TyG indexes and HUA was examined using restricted cubic spline(RCS).Results After a 3-year follow-up,146 participants developed incident HUA.Both TyG-mean and TyG index variability indicators were significantly higher in the HUA group compared to the non-HUA group(P<0.05).After adjusting for multiple confounders,each standard deviationσincrease in TyG-SD,TyG-CV,and adj-TyG-SD was associated with a 1.23-fold(95%CI 1.06-1.43),1.22-fold(95%CI 1.05-1.42),and 1.26-fold(95%CI 1.08-1.45)higher risk of incident HUA,respectively.RCS analysis revealed a nonlinear association between adj-TyG-SD and HUA risk(P<0.05),with a critical threshold of 0.55 at a hazard ratio(HR)of 1.Conclusions Increased TyG index variability is associated with a higher risk of incident HUA,with adj-TyG-SD showing the strongest correlation with HUA risk.

关 键 词：三酰甘油葡萄糖指数 变异性 高尿酸血症 队列研究 

分 类 号：R589.7[医药卫生—内分泌]