1例合并NAFLD和肝肾综合征的垂体柄中断综合征病例报道及文献复习  

Pituitary stalk interruption syndrome complicated with NAFLD and hepatorenal syndrome:A case report and literature review

作　　者：刘宏颖 伍学焱 Liu Hongying;Wu Xueyan(Department of Endocrinology,Peking Union Medical College Hospital,Chinese Academy of Medical Science&Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院,北京协和医院内分泌科,卫健委内分泌重点实验室,北京100730

出　　处：《中华内分泌代谢杂志》2025年第2期152-155,共4页Chinese Journal of Endocrinology and Metabolism

基　　金：北京市自然科学基金(7202151)。

摘　　要：垂体柄中断综合征(pituitary stalk interruption syndrome,PSIS)主要特点为垂体柄变薄或消失、垂体前叶发育不全和垂体后叶异位,本文回顾并分析了1例以双下肢水肿、肝肾功能异常、身材明显高于正常为主要临床表现的PSIS患者,通过对其临床表现、实验室检查、诊治经过的回顾,探讨垂体功能减退尤其是生长激素缺乏导致非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)及相关并发症内在机制并进行文献复习,提示临床中对于垂体功能减退出现肝肾功能异常患者需考虑该病可能,早期识别并及时治疗有助于改善患者预后。Pituitary stalk interrupt syndrome is characterized by pituitary stalk thinning or disappearance,anterior pituitary hypoplasia and posterior pituitary ectopic,this article reviewed and analyzed a case of PSIS presenting with bilateral lower limb edema,abnormal liver and kidney function,and significantly above-normal height.We explore the clinical manifestations,laboratory tests,diagnosis,and treatment of this case,as well as the potential underlying mechanisms of non-alcoholic fatty liver disease(NAFLD)and its related complications.The findings suggest that PSIS should be considered in patients with abnormal liver and kidney function.Early identification and timely intervention may improve patient prognosis.

关 键 词：垂体柄中断 垂体功能减退 非酒精性脂肪肝 肝肾综合征 不依赖生长激素的生长 

分 类 号：R58[医药卫生—内分泌]