棕色脂肪因子在棕色脂肪组织与其他器官相互交流中的作用及机制的研究进展  

Batokines in the cross-talk between brown adipose tissue and other organs:An update

作　　者：刘昊[1] 陈婕[1] 裘丹琦 徐开垒 励丽 陈淑芹 Liu Hao;Chen Jie;Qiu Danqi;Xu Kailai;Li Li;Chen Shuqin(Department of Endocrinology and Metabolism,the First Affiliated Hospital of Ningbo University,Ningbo 315000,China;Center for Medical and Engineering Innovation,the First Affiliated Hospital of Ningbo University,Ningbo 315000,China)

机构地区：[1]宁波大学附属第一医院内分泌科,宁波315000 [2]宁波大学附属第一医院医工交叉实验室,宁波315000

出　　处：《中华内分泌代谢杂志》2025年第2期156-163,共8页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金(82200978)。

摘　　要：棕色脂肪组织作为一种代谢活跃的器官,除了经典的产热作用外,还能通过内分泌功能调控自身及全身各器官系统的代谢功能。这一调控功能的实现主要是通过棕色脂肪组织分泌的物质——棕色脂肪因子(batokines)来实现。近年来,随着对棕色脂肪因子种类、靶器官及其作用机制研究的深入,棕色脂肪因子在棕色脂肪组织与其他器官之间的相互交流中的作用逐渐成为研究热点之一。本综述重点讨论棕色脂肪组织分泌的多种棕色脂肪因子,这些因子在调节棕色脂肪组织与肝脏、心血管系统、骨骼肌及神经系统等靶器官的相互作用中扮演重要角色。通过深入剖析这些因子的具体功能及作用机制,本文旨在为预防与治疗相关代谢性疾病开辟新的思路与研究方向。Brown adipose tissue(BAT),a metabolically active organ,not only plays a pivotal role in thermogenesis,but also exerts endocrine effects that regulate both its own metabolic processes and the function of various other organ systems.These effects are primarily mediated by brown adipose tissue-derived factors,or batokines.Recent advances in the understanding of batokine types,target organs,and underlying mechanisms have highlighted their significant role in the crosstalk between BAT and other organs.This review focuses on the various batokines secreted by BAT and their involvement in regulating interactions with key target organs such as the liver,cardiovascular system,skeletal muscle,and nervous system.By examining the specific functions and molecular mechanisms of these factors,this review aims to offer novel insights and suggest potential research directions for the prevention and treatment of related metabolic diseases.

关 键 词：棕色脂肪组织 棕色脂肪因子 代谢 器官交流 

分 类 号：R589[医药卫生—内分泌]