胰腺外分泌糖尿病的危险因素与发病机制研究进展  

Progress on the risk factors and pathogenesis of diabetes of the exocrine pancreas

作　　者：吕颖奇 朱转转 王丽 孙科 徐桂芳[4] 俞婷[5] 李玲[1] Lyu Yingqi;Zhu Zhuanzhuan;Wang Li;Sun Ke;Xu Guifang;Yu Ting;Li Ling(Department of Endocrinology,Zhongda Hospital,School of Medicine,Southeast University,Nanjing 210000,China;Department of Endocrinology,Zhenjiang No.1 People′s Hospital,Zhenjiang 212000,China;Department of Endocrinology,Yancheng No.3 People′s Hospital,Yancheng 224000,China;Department of Gastroenterology,Drum Tower Hospital,Nanjing University,Nanjing 210000,China;Department of Gastroenterology,Zhongda Hospital,School of Medicine,Southeast University,Nanjing 210000,China)

机构地区：[1]东南大学附属中大医院内分泌科,南京210000 [2]镇江市第一人民医院内分泌科,镇江212000 [3]盐城市第三人民医院内分泌科,盐城224000 [4]南京大学附属鼓楼医院消化科,南京210000 [5]东南大学附属中大医院消化科,南京210000

出　　处：《中华内分泌代谢杂志》2025年第2期164-167,共4页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金项目(82320108003、82170845);江苏省重点研发计划项目(BE2022853)。

摘　　要：胰腺外分泌糖尿病(DEP)是一类由胰腺外分泌疾病引发内分泌功能紊乱而导致的继发性糖尿病,胰腺癌风险显著升高,严重危害人类健康。最新流行病学数据表明,DEP已超越1型糖尿病,成为继2型糖尿病之后成人新发糖尿病的第二大常见类型。DEP的病因复杂多样,包括胰腺炎、胰腺癌、胰腺切除等,导致不同亚型患者的临床表现异质性大,规范化诊疗管理存在较大困难和挑战。本文就DEP的危险因素和发病机制研究进展作一综述,旨在为临床管理提供证据。Diabetes of the exocrine pancreas(DEP)refers to a complication of diseases of the exocrine pancreas,associated with an increased risk of pancreatic cancer.Recent evidence has indicated that DEP,after type 2 diabetes,has become the second most common type of adults-onset diabetes,with a higher prevalence than type 1 diabetes.DEP is not a single condition but encompasses various exocrine pancreatic disorders that lead to hyperglycemia through different mechanisms,creating significant diagnostic and therapeutic challenges.This review examines the latest research on the risk factors and pathogenesis of DEP,aiming to provide insights to improve its clinical management strategies.

关 键 词：胰腺外分泌糖尿病 糖尿病 3c型 糖尿病 胰源性 危险因素 发病机制 

分 类 号：R587.1[医药卫生—内分泌]