沙利度胺及其衍生物在人类免疫缺陷病毒感染相关疾病中的应用  

Application of thalidomide and its derivatives in human immunodeficiency virus infection-related diseases

作　　者：任玲 但红霞 Ren Ling;Dan Hongxia(State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,Research Unit of Oral Carcinogenesis and Management,Chinese Academy of Medical Sciences,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病防治全国重点实验室,国家口腔疾病临床医学研究中心,口腔黏膜病国家临床重点专科,中国医学科学院口腔黏膜癌变与防治创新单元,四川大学华西口腔医院口腔黏膜病科,成都市610041

出　　处：《中华实验和临床感染病杂志(电子版)》2024年第6期321-326,共6页Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)

基　　金：国家自然科学基金面上项目(No.82370965)。

摘　　要：人类免疫缺陷病毒(HIV)感染者易发生各种机会性感染及肿瘤,临床及病理表现往往较为复杂,临床治疗棘手,预后不佳。沙利度胺及其衍生物在抗炎、免疫调节和抗肿瘤等方面具有广泛药理作用,近些年来越来越多地被应用于黏膜溃疡、结节性痒疹、机会性感染、免疫重建炎症综合征、卡波西肉瘤、非霍奇金淋巴瘤和Castleman病等HIV感染相关疾病中。本文主要对沙利度胺及其衍生物在上述疾病中的应用进行综述。Patients infected with human immunodeficiency virus(HIV)are susceptible to various opportunistic infections and tumors.These diseases often have complex clinical and pathological manifestations,poor prognosis and are difficult to manage.Thalidomide and its derivatives have a wide range of pharmacological effects including antiinflammatory,immunomodulatory and anti-tumor activities.In recent years,thalidomide and its derivatives have been increasingly used in HIV infection-related diseases,mainly including mucosal ulcer,prurigo nodosa,opportunistic infection,immune reconstruction inflammatory syndrome,Kaposi sarcoma,non-Hodgkin lymphoma and Castleman disease.This paper mainly reviews the application of thalidomide and its derivatives in the above diseases.

关 键 词：人类免疫缺陷病毒 获得性免疫缺陷综合征 沙利度胺 免疫调节酰亚胺药物 

分 类 号：R512.91[医药卫生—内科学]