血浆氧化三甲胺水平与心房颤动相关  

Association between plasma trimethylamine N-oxide level and atrial fibrillation

作　　者：杨文涛 赵清 李向东 王玉堂[3] 刘巍 YANG Wentao;ZHAO Qing;LI Xiangdong;WANG Yutang;LIU Wei(Department of Cardiology,Beijing Jishuitan Hospital,Capital Medical University,Beijing 100035;Department of Cardiology,the First Medical Center,Chinese People′s Liberation Army General Hospital,Beijing 100853;Department of Cardiology,the Second Medical Center and National Clinical Research Center for Geriatric Diseases,Chinese People′s Liberation Army General Hospital,Beijing 100853,China)

机构地区：[1]首都医科大学附属北京积水潭医院心血管内科,北京100035 [2]解放军总医院第一医学中心心血管内科,北京100853 [3]解放军总医院第二医学中心心血管内科,国家老年疾病临床医学研究中心,北京100853

出　　处：《基础医学与临床》2025年第4期499-504,共6页Basic and Clinical Medicine

基　　金：北京自然科学基金(Z141100002114050)。

摘　　要：目的探讨血浆氧化三甲胺(TMAO)水平与心房颤动(AF)之间的关联。方法共纳入257例AF患者,其中阵发性AF 114例、持续性AF 143例;以及122例非AF患者作为对照;测量血浆TMAO水平并收集患者的人口特征及临床资料,进行回归分析以探索血浆TMAO水平与AF是否有关联。结果AF患者的血浆TMAO水平高于非AF患者(3.9[2.4~5.9]vs.2.4[1.6~3.7]μmol/L,P<0.001);经过年龄、糖尿病、高血压、心力衰竭、身体质量指数的多因素校正,TMAO水平仍与AF显著相关(OR:1.29,95%CI:1.151~1.445;P<0.001);在AF患者中,持续性AF患者血浆中的TMAO水平高于阵发性AF组(4.4[2.8~6.8]vs.3.2[2.2~5.0]μmol/L,P<0.01);经过年龄、高血压、糖尿病、心力衰竭、冠心病的多因素校正,血浆TMAO水平与持续性AF仍存在关联(OR:1.092,95%CI:1.009~1.182;P=0.029)。结论AF患者的血浆TMAO水平高于非AF患者,升高的血浆TMAO水平与AF风险增加相关;在AF患者中,血浆TMAO水平升高与持续性AF的风险增加相关。Objective To explore the relationship between plasma trimethylamine N-oxide(TMAO)level and atrial fibrillation(AF)by a clinical trial.Methods Totally 257 patients with AF were enrolled including 114 patients with paroxysmal AF and 143 with persistent AF.The control group had 122 non-AF patients;Plasma TMAO level,the demographic characteristics and clinical data of patients were collected.Regression analysis was performed to identify the association between TMAO and presence of AF.Results Plasma TMAO level of patients with AF was higher than that of patients without AF(3.9[2.4-5.9]vs.2.4[1.6-3.7]μmol/L,P<0.001);Even after adjust-ment of confounding factors including age,hypertension,diabetes,heart failure and body mass index;Plasma TMAO level was still related to presence of AF(OR:1.290,95%CI:1.151-1.445;P<0.001).The plasma TMAO level of patients with persistent AF was higher than that of patients with paroxysmal AF(4.4[2.8-6.8]vs.3.2[2.2-5.0]μmol/L,P<0.01);Even after adjustment of confounding factors including age,hypertension,diabetes and heart failure and coronary heart disease;Plasma TMAO level was still related to persistent AF(OR:1.092,95%CI:1.009-1.182;P=0.029).Conclusions The level of plasma TMAO of patients with AF is higher than that of patients without AF.Elevated plasma TMAO level is related to an increased risk of AF.Elevated plasma TMAO level in patients with AF is related to an increased risk of persistent AF.

关 键 词：氧化三甲胺 心房颤动 阵发性房颤 持续性房颤 

分 类 号：R541.7[医药卫生—心血管疾病]