变应性支气管肺曲霉病复发患者血清半乳甘露聚糖水平与烟曲霉特异性抗体相关  

Correlation between serum galactomannano level and Aspergillus fumigatus specific antibody in patients with allergic bronchopulmonary aspergillus recurrence

作　　者：王文陶 谭薇[2] WANG Wentao;TAN Wei(School of Clinical Medicine,Shandong Second Medical University,Weifang 261053;Department of Respiratory and Critical Care Medicine,Weifang People′s Hospital,Weifang 261041,China)

机构地区：[1]山东第二医科大学临床医学院,山东潍坊261053 [2]潍坊市人民医院呼吸与危重症医学科,山东潍坊261041

出　　处：《基础医学与临床》2025年第4期511-516,共6页Basic and Clinical Medicine

基　　金：潍坊市中医药科学技术研究项目(CX120456)。

摘　　要：目的探究变应性支气管肺曲霉病(ABPA)复发患者血清半乳甘露聚糖(GM)水平与烟曲霉特异性抗体水平的关系。方法回顾性分析2020年6月—2023年6月确诊并经激素治疗ABPA的124例患者作为研究对象,以治疗后复发情况分组为非复发组(n=72)和复发组(n=52)。分别记录两组患者的临床资料、血常规指标、GM以及烟曲霉特异性抗体水平。结果复发组患者年龄、白细胞(WBC)、中性粒细胞(NEU)、淋巴细胞(LYM)、嗜酸性粒细胞数(EOS)、GM、血清总免疫球蛋白E(tIgE)、烟曲霉特异性免疫球蛋白E(sIgE)和烟曲霉特异性免疫球蛋白G(sIgG)水平均高于非复发组患者(P<0.05)。GM与sIgE、sIgG之间存在一定的非线性关系(P<0.05)。GM、sIgE、sIgG均与ABPA复发风险存在独立相关性(P<0.05),与ABPA复发风险呈非线性剂量-反应关系(P for non linear<0.005)。不同GM水平下、sIgE、sIgG越高,ABPA复发率越高。GM与sIgE、sIgG存在交互作用。结论GM,sIgE、sIgG升高,ABPA复发率升高。ABPA复发患者血清GM水平与烟曲霉特异性抗体相关。Objective To explore the relationship between serum galactomannano(GM)level and specific antibody level of Aspergillus fumigatus in patients with allergic bronchopulmonary aspergillus(ABPA)recurrence.Methods A total of 124 patients diagnosed with ABPA and treated with hormone therapy in our hospital from June 2020 to June 2023 were retrospectively analyzed.According to the recurrence after treatment,the patients were divided into non-recurrence group(n=72)and recurrence group(n=52).The clinical data,blood routine indicators,GM and Aspergillus fumigatus specific antibody level of the two groups were recorded.Results Age,white blood cell(WBC),neutrophil(NEU),lymphocyte(LYM),eosinophil(EOS),GM,serum total immunoglobulin E(tIgE),Aspergillus fumigatus specific immunoglobulin E(sIgE)and Aspergillus fumigatus specific immunoglobulin G(sIgG)were higher in the recurrence group than in the non-recurrence group(P<0.05).There was a nonlinear relationship between GM and sIgE/sIgG(P<0.05).GM,sIgE and sIgG were independently correlated with the risk of ABPA recurrence(P<0.05),and had a nonlinear dose-response relationship with the risk of ABPA recurrence(P for non linear<0.05).Under different GM level,the higher the sIgE and sIgG,the higher the ABPA recurrence rate.There was an interaction between GM and sIgE/sIgG.Conclusions With the increase of GM,sIgE and sIgG level,the recurrence rate of ABPA increases.Serum GM level in ABPA recurrence patients is correlated with Aspergillus fumigatus specific antibody.

关 键 词：变应性支气管肺曲霉病 复发 半乳甘露聚糖 烟曲霉特异性免疫球蛋白G 烟曲霉特异性免疫球蛋白E 

分 类 号：R379.6[医药卫生—病原生物学]