穿孔素2的研究进展  

Research progress of perforin 2

作　　者：邓智渊 白璐 玉荣 DENG Zhiyuan;BAI Lu;YU Rong(Department of Radiation Oncology,Peking University Cancer Hospital(Inner Mongolia Campus)&Affiliated Cancer Hospital of Inner Mongolia Medical University,Hohhot 010020;Department of Pathology,Peking University Cancer Hospital(Inner Mongolia Campus)&Affiliated Cancer Hospital of Inner Mongolia Medical University,Hohhot 010020;Graduate School,Inner Mongolia Medical University,Hohhot 010110,China)

机构地区：[1]北京大学肿瘤医院内蒙古医院,内蒙古医科大学附属肿瘤医院放疗科,内蒙古呼和浩特010020 [2]北京大学肿瘤医院,内蒙古医院内蒙古医科大学附属肿瘤医院病理科,内蒙古呼和浩特010020 [3]内蒙古医科大学研究生院,内蒙古呼和浩特010110

出　　处：《基础医学与临床》2025年第4期542-545,共4页Basic and Clinical Medicine

基　　金：内蒙古自治区高等学校“青年科技英才支持项目”(NJYT23073);内蒙古医科大学“致远”人才计划项目(ZY20242147)。

摘　　要：穿孔素2(又称MPEG1)是膜攻击复合物/穿孔素MACPF超家族中的一种蛋白,主要由细胞毒性T淋巴细胞、自然杀伤细胞和巨噬细胞分泌,通过在靶细胞膜上形成活性孔道使靶细胞渗透压改变而溶解,或者与颗粒酶协同作用而诱导靶细胞凋亡。近年来,随着分子生物学的发展,对MPEG1的研究越来越深入,穿孔素2所特有的基因序列、蛋白表达的细胞类型等使其在不同免疫细胞中具有特定功能和适应性演化,这可能决定了其在不同疾病状态下的表现和治疗潜力。Perforin 2(MPEG 1)is a member of the MACPF(membrane attack complex/PRF membrane attack complex/perforin)superfamily,which is mainly secreted by cytotoxic T lymphocytes,natural killer cells and macrophages Through the formation of active pores on the target cell membrane,perforin 2 participates in altering the permeability-pressure of the target cell,or collaborates with granzymes to induce the apoptosis of target cells.Recently,with the development of molecular biology,MPEG 1 has been increasingly studied,and the unique gene sequence and cell types of perforin 2 have specific functions and adaptive evolution in different immune cells,which may determine its performance and therapeutic potential in different disease states.

关 键 词：穿孔素2 MPEG1 膜攻击复合物穿孔素 成孔蛋白 

分 类 号：R392[医药卫生—免疫学]