细胞程序性死亡在多囊卵巢综合征中的作用  

The role of programmed cell death in PCOS

作　　者：刘科慧 杜琛[2] 陈秀娟[2] LIU Ke-hui;DU Chen;CHEN Xiu-juan(Inner Mongolia Medical University,Hohhot 010050;Center for Reproductive Medicine,the Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050)

机构地区：[1]内蒙古医科大学,呼和浩特010050 [2]内蒙古医科大学附属医院生殖医学中心,呼和浩特010050

出　　处：《生殖医学杂志》2025年第4期566-570,共5页Journal of Reproductive Medicine

基　　金：内蒙古自治区自然科学基金(2023LHMS08054);内蒙古自治区科技攻关计划(2022YFSH0067)。

摘　　要：女性不孕症的常见病因——多囊卵巢综合征(PCOS)的病因病理未完全明确,是生殖领域一直以来研究的重点,其最主要的临床特征为排卵障碍。除了遗传因素、胰岛素抵抗及高雄激素血症与排卵障碍之间的关系研究,目前包括细胞凋亡、自噬、坏死性凋亡、焦亡及铁死亡等在内的细胞程序性死亡(PCD)由于参与了卵泡闭锁、排卵障碍的发生,也是PCOS病因病理的研究方向。本文就细胞程序性死亡在PCOS中的作用予以综述,以期为PCOS的预防、诊断和治疗提供新方向,为辅助生殖技术提供新的理念。The etiology and pathology of PCOS,a popular cause of female infertility,is not completely clear,which has been the focus of research in the field of reproduction,and its main clinical feature is ovulation disorder.In addition to genetic factors,the relationship between insulin resistance,hyperandrogenism and ovulation disorder,programmed cell death(PCD),including apoptosis,autophagy,necroptosis,pyroptosis and ferroptosis discovered in recent years,is also the research direction of etiology and pathology of PCOS.This article reviews the role of PCD in PCOS to provide new directions for the prevention,diagnosis,and treatment of PCOS,as well as new concepts for ART.

关 键 词：多囊卵巢综合征 卵巢颗粒细胞 细胞程序性死亡 焦亡 

分 类 号：R711.75[医药卫生—妇产科学]