上海市松江区≥60岁老年人接种23价肺炎球菌多糖疫苗预防社区获得性肺炎保护效果的真实世界研究  

Real-world effectiveness of 23-valent pneumococcal polysaccharide vaccine against community-acquired pneumonia among elderly people≥60 years of age in Songjiang district of Shanghai

作　　者：张文翠[1] 白庆瑞[2] 奚超 张方芳 王伟 李静 蒋利华 吴毅凌[1] Zhang Wencui;Bai Qingrui;Xi Chao;Zhang Fangfang;Wang Wei;Li Jing;Jiang Lihua;Wu Yiling(Songjiang District Center for Disease Control and Prevention,Shanghai 201620,China;Shanghai Center for Disease Control and Prevention,Shanghai 201600,China;Xinqiao Town Community Health Service Center,Songjiang District,Shanghai 201620,China;Zhongshan Street Community Health Service Center,Songjiang District,Shanghai 201620,China;Sheshan Town Community Health Service Center,Songjiang District,Shanghai 201620,China)

机构地区：[1]上海市松江区疾病预防控制中心,上海201620 [2]上海市疾病预防控制中心,上海201600 [3]松江区新桥镇社区卫生服务中心,上海201620 [4]松江区中山街道社区卫生服务中心,上海201620 [5]松江区佘山镇社区卫生服务中心,上海201620

出　　处：《中国疫苗和免疫》2025年第1期36-40,共5页Chinese Journal of Vaccines and Immunization

基　　金：上海市加强公共卫生体系建设三年行动计划(2023-2025年)重点学科建设项目(GWVI-11.1-23)。

摘　　要：目的评价≥60岁老年人接种23价肺炎球菌多糖疫苗(23-valent pneumococcal polysaccharide vaccine,PPV23)预防社区获得性肺炎(Community-acquired pneumonia,CAP)的保护效果(Vaccine effectiveness,VE)。方法2016年4月-2017年9月在上海市松江区招募首次接种和未接种PPV23的≥60岁人群开展前瞻性队列研究,观察截至2019年底两组CAP发病密度。采用Cox比例风险回归模型分析两组CAP发病风险比(Hazard ratio,HR),估算PPV23预防CAP的VE。结果PPV23接种组、未接种组研究对象在观察期间CAP发病密度分别为1.33/100人年(48/3615.94)、1.99/100人年(349/17557.31),两组CAP发病的HR为0.68(95%CI:0.49~0.96),PPV23预防CAP的VE为31.66%(95%CI:4.44%~51.13%);经调整年龄后的VE为29.94%(95%CI:1.61%~50.11%)。结论60岁老年人接种PPV23对预防CAP发病具有显著保护效果;建议老年人及时接种PPV23。Objective To evaluate the vaccine effectiveness(VE)of 23-valent pneumococcal polysaccharide vaccine(PPV23)against community-acquired pneumonia(CAP)in elderly people≥60 years of age.Methods We recruited≥60-year-olds who had received one dose of PPV23 and≥60-year-olds who had not received PPV23 during April 2016 to September 2017 in Songjiang district of Shanghai and conducted a prospective cohort study.We determined incidence densities of CAP in the two groups to estimate their hazard ratio(HR)and the PPV23 VE against CAP using a Cox proportional hazard regression model.Results CAP incidence densities were 1.33 per 100 person-years(48 cases in 3615.94 person-years)in the PPV23 vaccinated group and 1.99 per 100 person-years(349 cases in 17557.31 person-years)in the unvaccinated group during the observation period.The HR was 0.68(95%CI:0.49 to 0.96)and the VE of PPV23 against CAP was 31.66%(95%CI:4.44%to 51.13%).Age-adjusted VE was 29.94%(95%CI:1.61%to 50.11%).Conclusions PPV23 vaccination provided significant protection against CAP among≥60-year-olds.We recommend that elderly individuals receive PPV23.

关 键 词：23价肺炎球菌多糖疫苗 预防接种 社区获得性肺炎 发病密度 风险比 保护效果 

分 类 号：R186[医药卫生—流行病学] R183.3[医药卫生—公共卫生与预防医学]