载脂蛋白B/载脂蛋白A1比值与泛血管疾病关联的研究进展  

Research progress on the association between apolipoprotein B/apolipoprotein A1 ratio and pan-vascular diseases

作　　者：王白菊 李含 刘雷[1] 陈汉文 Wang Baiju;Li Han;Liu Lei;Chen Hanwen(Department of General Medicine,Affiliated Hospital of Jining Medical College,Jining 272029,China)

机构地区：[1]济宁医学院附属医院全科医学科,济宁272029

出　　处：《中华全科医师杂志》2025年第4期496-500,共5页Chinese Journal of General Practitioners

摘　　要：以动脉粥样硬化为共同病理特征的系统性血管疾病被称为泛血管疾病。近年来泛血管疾病的发病率和死亡率均呈上升趋势。传统危险因素无法完全解释泛血管疾病的发生发展,而载脂蛋白基因多态性与动脉粥样硬化的发生发展密切相关,或可作为其的一种生物标志物。该文综述了载脂蛋白B(ApoB)/载脂蛋白A1(ApoA1)比值与泛血管疾病关联的研究进展。随着研究的不断深入,ApoB/ApoA1比值在不同泛血管疾病人群中的特异性表现及其对不同干预措施的反应,或可有助于实现更加精准、个性化的疾病管理,改善患者预后。Systemic vascular diseases characterized by a common pathological feature of atherosclerosis are referred to as pan-vascular disease,the incidence and mortality of which are increasing currently.Apolipoproteins are closely related to the occurrence of atherosclerosis due to their genetic polymorphism,and expected to become new biomarkers for prediction and intervention of the disease.This article reviews the research progress on the biological functions of apolipoproteins,and the association of the apolipoprotein B(ApoB)/apolipoprotein A1(ApoA1)ratio with the pathogenesis and progress of atherosclerosis.Understanding the ApoB/ApoA1 ratio in different populations with pan-vascular diseases and its effects on different interventions will be conducive to precise and personalized disease management,and to improve clinical outcomes and the quality of life of patients.

关 键 词：动脉粥样硬化 载脂蛋白A类 载脂蛋白B类 泛血管疾病 

分 类 号：R543[医药卫生—心血管疾病]