静坐时长和体力活动与男性精子质量的关联研究  

Research on the association between sedentary duration,physical activity,and male sperm quality

作　　者：曾思漩 杨婷婷 李福平[2,3] 田润 张璐 付鹏波 符乐瑶 宋贵双 廖俊豪 于川 肖成汉 刘振谧 ZENG Si-xuan;YANG Ting-ting;LI Fu-ping;TIAN Run;ZHANG Lu;FU Peng-bo;FU Le-yao;SONG Gui-shuang;LIAO Jun-hao;YU Chuan;XIAO Cheng-han;LIU Zhen-mi(West China School of Public Health/West China Fourth Hospital,Sichuan University,Chengdu,Sichuan 610041,China;不详)

机构地区：[1]四川大学华西公共卫生学院/华西第四医院,四川成都610041 [2]四川大学华西第二医院生殖男科/四川省人类精子库 [3]西部妇幼研究院出生缺陷与相关妇儿疾病教育部重点实验室

出　　处：《现代预防医学》2025年第5期786-794,800,共10页Modern Preventive Medicine

基　　金：国家自然科学基金区域创新发展联合基金(U23A202600)。

摘　　要：目的 探究静坐时长和体力活动与男性精子质量之间的关联。方法 基于来自四川省人类精子库的1 578份精液样本,采用调整线性回归模型和限制性立方样条分析每日静坐时长、每周体力活动量、体力活动水平与常规精液指标和精子动力学指标的线性与非线性关联。结果 每日静坐时长和每周体力活动量与前向精子、不运动精子、总活力等呈显著非线性关联(P<0.05);每周体力活动量还与平均曲线速度、平均路径速度、平均直线速度和平均鞭打频率等呈显著非线性关联(P<0.05);相较于低水平组,中、高体力活动水平组的前向精子[%Change(95%CI):4.302(1.691~6.979)、2.816(0.227~5.472)]、总活力[%Change(95%CI):3.624(1.227~6.079)、2.567(0.179~5.012)]、平均曲线速度[%Change(95%CI):6.600(3.021~10.304)、3.958(0.446~7.594)]、平均路径速度[%Change(95%CI):6.529(2.987~10.193)、4.012(0.532~7.613)]、平均直线速度[%Change(95%CI):5.992(2.049~10.087)、4.221(0.319~8.274)]等指标有显著提升,尤其中体力活动水平组有更明显的改善。结论 每日静坐时长过少或过长均是男性精子质量的风险因素,静坐时长过少可能潜在危害更大,保持规律适度的体力活动则有益于改善精子质量。Objective To investigate the association between sedentary duration,physical activity,and male sperm quality.Methods Based on 1578 semen samples from the Sichuan Human Sperm Bank,a linear regression model and restricted cubic spline analysis were employed to examine the linear and nonlinear associations of daily sedentary duration,weekly physical activity volume,and physical activity level with conventional semen parameters and sperm kinetic parameters.Results Daily sedentary duration and weekly physical activity volume showed significant nonlinear associations with forward motility,immotility,and total motility(P<0.05).Additionally,weekly physical activity volume was significantly nonlinearly associated with average curvilinear velocity,average path velocity,average straight-line velocity,and average flagellar beat frequency(P<0.05).Compared to the low activity group,the moderate and high activity groups had significant improvements in forward motility[%Change(95%CI):4.302(1.691-6.979),2.816(0.227-5.472)],total motility[%Change(95%CI):3.624(1.227-6.079),2.567(0.179-5.012)],average curvilinear velocity[%Change(95%CI):6.600(3.021-10.304),3.958(0.446-7.594)],average path velocity[%Change(95%CI):6.529(2.987-10.193),4.012(0.532-7.613)],and average straight-line velocity[%Change(95%CI):5.992(2.049-10.087),4.221(0.319-8.274)],with the moderate activity group showing more pronounced improvements.Conclusion Both insufficient and excessive daily sedentary duration are risk factors for male sperm quality,with insufficient sedentary duration potentially posing greater harm.Maintaining regular and moderate physical activity is beneficial for improving sperm quality.

关 键 词：静坐时长 体力活动 精子质量 横断面研究 

分 类 号：R169.1[医药卫生—公共卫生与预防医学] R698.2R321.1