复发性外阴阴道念珠菌病患者临床和真菌学特征以及对生活质量的影响  

Clinical and fungal characteristics of patients with recurrent vulvovaginal candidiasis and their impact on quality of life

作　　者：王晶晶[1] 王琳琳 张佳佳[1] WANG Jing-jing;WANG Lin-lin;ZHANG Jia-jia(Department of Obstetrics and Gynecology,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第三附属医院妇科,郑州450052

出　　处：《医药论坛杂志》2025年第5期491-494,499,共5页Journal of Medical Forum

摘　　要：目的观察复发性外阴阴道念珠菌病(recurrent vulvovaginal candidiasis,RVVC)患者的真菌学特征以及对生活质量(health-related quality of life,HRQOL)的影响。方法选取郑州大学第三附属医院2022年6月至2023年12月的RVVC患者102例,同期普通保健妇女101例为对照组。健康调查简表(SF-36)测量HRQOL,比较不同患者及治疗随访6个月后SF-36得分,分析SF-36得分与VVC得分的相关性。结果RVVC患者平均病程(23.28±11.75)个月,最常见的主诉是阴道分泌物增多(100%)、瘙痒(95.10%)、性交困难(63.73%)、灼烧(77.45%)和红斑(24.51%),感染白色念珠菌(84.31%),热带假丝酵母菌(11.76%)和克柔念珠菌(0.98%)。RVVC患者基线生理功能、生理职能、生活活力、身体疼痛、总体健康状况、社会功能、情感功能、和心理健康各领域得分,以及身体总分(physical component summary,PCS)和心理总分(mental compoment summary,MCS)均低于对照组和RVVC患者6个月随访时得分。PCS和MCS得分与VVC得分负相关。白色念珠菌感染患者PCS和MCS得分低于非白色念珠菌感染者,VVC>6分患者PCS和MCS得分低于VVC≤6患者。结论RVVC主要由白色念珠菌引起,对女性的HRQOL有负面影响,患者身体和心理综合得分与白色念珠菌感染和症状严重程度有关,6个月的维持治疗可有效改善生活质量,但仍低于健康人群。Objective To observe the fungal characteristics and their impact on health-related quality of life(HRQOL)in patients with recurrent vulvovaginal candidiasis(RVVC).Methods Totally 102 patients with RVVC treated in from June 2022 to December 2023 were selected,and 101 women with general health care during the same period were selected as the control group.The Short Form of Health Survey(SF-36)measure HRQOL,compare SF-36 scores among differ-ent patients and after 6 months of treatment follow-up,and analyze the correlation between SF-36 scores and VVC scores.Results The average course of RVVC patients was(23.28±11.75)months,and the most common chief com-plaints were increased vaginal discharge(100%),itching(95.10%),difficulty in sexual intercourse(63.73%),burn-ing(77.45%),and erythema(24.51%),infection with Candida albicans(84.31%),tropical Candida(11.76%),and Candida krusei(0.98%).The baseline physiological function,physiological function,vitality,physical pain,overall health status,social function,emotional function,psychological health scores mental compoment summary(MCS)and physical component summary(PCS)of RVVC patients were lower than those of the control group and RVVC patients at 6-month follow-up.PCS and MCS scores were negatively correlated with VVC scores.The PCS and MCS scores of pa-tients with Candida albicans infection were lower than those of non Candida albicans infection,and the PCS and MCS scores of patients with VVC>6 are lower than those of patients with VVC≤6.Conclusion RVVC is mainly caused by Candida albicans,which has a negative impact on HRQOL in women.The comprehensive physical and psychological scores of patients are related to the severity of Candida albicans infection and symptoms.Maintenance treatment for 6 months can effectively improve quality of life,but it is still lower than that of healthy individuals.

关 键 词：真菌感染 复发性外阴阴道念珠菌感染 健康相关生活质量 SF-36 白色念珠菌 

分 类 号：R711.31[医药卫生—妇产科学]