基于肝肾—天癸—冲任—乳轴辨治乳腺癌类更年期综合征  

Treatment of breast cancer-associated menopause-like syndrome based on the Liver-Kidney-Tiangui-Chongren-Breast Axis

作　　者：崔瑞芳 李仁廷[1] 纪长隆 高孔雀 张亚茹 CUI Ruifang;LI Renting;JI Zhanglong;GAO Kongque;ZHANG Yaru(Shaanxi University of Chinese Medicine,Xianyang 712046)

机构地区：[1]陕西中医药大学,咸阳712046

出　　处：《现代中医临床》2025年第2期70-73,共4页Modern Chinese Clinical Medicine

基　　金：陕西省名中医传承工作室建设项目(No.2019003);陕西省中医药管理局中医药科学技术研究课题(No.2019-ZZ-JC043)。

摘　　要：乳腺癌内分泌治疗是降低患者复发风险的重要方式,类更年期综合征是伴随的常见不良反应,严重阻碍治疗进程。中医药作为内分泌治疗的联合治疗具有独特优势。肝肾—天癸—冲任—乳轴的理论阐释包括:肝肾气血充盛,乳络滋养有源;天癸至,乳络滋养有形;任通冲盛,乳络滋养有径。肝肾—天癸—冲任—乳轴与乳腺癌内分泌相关类更年期综合征的关系表现在:肝肾—天癸—冲任—乳轴失调为发病基础,肝郁肾亏、冲任不调为病机关键。基于肝肾—天癸—冲任—乳轴诊治类更年期综合征,包括:调肝为重,身心通调;理气和血,调摄冲任;益肾固本,调整阴阳。Endocrine therapy plays a crucial role in reducing the risk of recurrence for breast cancer. A common adverse effect that significantly impedes the treatment progress is the menopause-like syndrome. Traditional Chinese Medicine offers unique advantages as a complementary therapy to modern endocrine treatment. The theoretical explanation of the Liver-Kidney-Tiangui-Chongren-Breast Axis encompasses: when the liver and kidney are abundant in qi and blood, the mammary collaterals are nourished and active;with the arrival of Tiangui, the mammary collaterals become tangibly nourished;when the Chongren meridians are in balance, the mammary collaterals are nourished with a defined pathway. The relationship between the Liver-Kidney-Tiangui-Chongren-Breast Axis and endocrine-associated menopause-like syndrome in breast cancer is as follows: Dysregulation of this axis forms the basis of pathogenesis, with liver stagnation, kidney deficiency, and imbalance of the Chongren being key pathogenesis factors. Diagnosis and treatment of menopause-like syndrome based on the axis include: prioritizing liver regulation, harmonizing both body and mind;regulating qi and blood, balancing the Chongren;nourishing the kidney and consolidating the foundation, and adjusting yin and yang.

关 键 词：肝肾—天癸—冲任—乳轴 乳腺癌 类更年期综合征 

分 类 号：R273[医药卫生—中西医结合] R271.9[医药卫生—中医肿瘤科]