孟鲁司特钠治疗小儿反复上呼吸道感染的临床疗效及对肺功能的影响  

Clinical efficacy of montelukast sodium in the treatment of recurrent upper respiratory tract infections in children and its impact on lung function

作　　者：李传花 任会婧 郭峰 吴冬 Li Chuanhua;Ren Huijing;Guo Feng;Wu Dong(Yiyuan County People's Hospital,Zibo,Shandong,256100,China)

机构地区：[1]沂源县人民医院,山东淄博256100

出　　处：《中国医学文摘(耳鼻咽喉科学)》2025年第2期133-135,142,共4页Chinese Medical Digest(Otorhinolaryngology)

摘　　要：目的探究小儿反复上呼吸道感染采取孟鲁司特钠诊疗的效果及指标改善影响。方法选取小儿反复上呼吸道感染患儿80例作为研究对象,均于2022年1月~2023年1月收入,按随机数表法分组,一组(对照组,40例)予维生素A软胶囊,一组(治疗组,40例)予维生素A软胶囊+孟鲁司特钠,比较指标:临床疗效、肺功能、免疫功能、不良反应。结果①临床疗效:治疗组诊疗后,所测得临床疗效较对照组高(P<0.05);②肺功能:治疗组诊疗后,所测得肺功能(FVC、FEV1等)改善效果较对照组高(P<0.05);③免疫功能:治疗组诊疗后,所测得免疫功能(IgA、IgG)改善效果较对照组高(P<0.05);④不良反应、复发率:治疗组诊疗后,所测得不良反应较对照组无显著差异(P>0.05);基于复发率上,治疗组低于对照组(P<0.05)。结论小儿反复上呼吸道感染采取孟鲁司特钠诊疗效果显著,可改善肺功能,发挥免疫调节作用,且复发率低,安全性较高,值得借鉴。Objective To explore the effect of using montelukast sodium for diagnosis and treatment of recurrent upper respiratory tract infections in children and the impact of indicator improvement.Method Eighty children with recurrent upper respiratory tract infections were selected as the study subjects,all of whom were enrolled from January 2022 to January 2023.They were randomly divided into two groups using a random number table method:one group(control group,40 cases)received vitamin A soft capsules,and the other group(treatment group,40 cases)received vitamin A soft capsules+montelukast sodium.The comparative indicators were clinical efficacy,lung function,immune function,and adverse reactions.Result①Clinical efficacy:After diagnosis and treatment,the clinical efficacy measured in the treatment group was higher than that in the control group(P<0.05);②Pulmonary function:After diagnosis and treatment,the improvement effect of lung function(FVC,FEV1,etc.)measured in the treatment group was higher than that in the control group(P<0.05)Immune function:After diagnosis and treatment,the improvement effect of the measured immune function(IgA,IgG)in the treatment group was higher than that in the control group(P<0.05)Adverse reactions and recurrence rate:After diagnosis and treatment,there was no significant difference in the measured adverse reactions between the treatment group and the control group(P>0.05);Based on the recurrence rate,the treatment group was lower than the control group(P<0.05).Conclusion The use of montelukast sodium in the diagnosis and treatment of recurrent upper respiratory tract infections in children has a significant effect,can improve lung function,exert immune regulatory effects,and has a low recurrence rate and high safety,which is worth learning from.

关 键 词：小儿反复上呼吸道感染 孟鲁司特钠 免疫功能 肺功能 

分 类 号：R725.6[医药卫生—儿科]