冠状动脉疾病患者药物洗脱支架术后主要不良心脑血管事件发生的影响因素分析  

Analysis of influencing factors of major adverse cardio-cerebrovascular events after drug-eluting stenting in patients with coronary artery disease

作　　者：孟昭昀 张燕群 王秀玲 MENG Zhao-yun;ZHANG Yan-qun;WANG Xiu-ling(Department of General Medicine,Jinan People's Hospital,Jinan,Shandong,271100,China)

机构地区：[1]济南市人民医院全科医学科,山东济南271100 [2]济南市人民医院心血管内科,山东济南271100 [3]济南市人民医院心电图室,山东济南271100

出　　处：《心血管康复医学杂志》2025年第2期135-139,共5页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探讨冠状动脉疾病(CAD)患者药物洗脱支架(DES)术后主要不良心脑血管事件(MACCE)发生的影响因素。方法:从Dryad数据库中提取郑州大学第一附属医院的回顾性研究数据。根据随访期内是否发生MACCE将患者分为MACCE组(n=160)和对照组(n=880)。对比两组患者的年龄、性别、纤维蛋白原水平等临床资料,将组间比较有显著差异的变量代入Logistic回归模型,筛选CAD患者DES术后MACCE发生的影响因素。结果:与对照组相比,MACCE组患者纤维蛋白原水平[(3.6±1.1)g/L比(3.4±1.0)g/L]显著升高、3支病变(25.6%比18.3%)、累及右冠状动脉比例(53.1%比41.7%)显著增多(P<0.05或<0.01)。多因素Logistic回归分析显示纤维蛋白原水平(OR=1.18,95%CI 1.01~1.37,P=0.039)是CAD患者DES术后发生MACCE的独立危险因素。当纤维蛋白原水平>3.27g/L时,CAD患者DES术后MACCE发生的风险显著增加。结论:高纤维蛋白原水平是CAD患者DES术后发生MACCE的独立危险因素。Objective:To explore the influencing factors of major adverse cardio-cerebrovascular events(MACCE)after drug-eluting stenting in patients with coronary artery disease(CAD).Methods:Retrospective study data from First Affiliated Hospital of Zhengzhou University were extracted from the Dryad database.Patients were divided into MACCE group(n=160)and control group(n=880)according to whether MACCE occurred during follow-up.Clinical data including age,gender,fibrinogen(Fg)level etc.were compared between two groups,and the variables with significant differences between two groups were substituted into Logistic regression model to screen the influencing factors of MACCE after drug eluting stenting in CAD patients.Results:Compared with patients in control group,those in MACCE group had significant higher Fg level[(3.6±1.1)g/L vs.(3.4±1.0)g/L],proportions of triple-vessel coronary disease(25.6%vs.18.3%)and right coronary artery lesion(53.1%vs.41.7%)(P<0.05 or<0.01).Multivariate Logistic regression analysis indicated that Fg level(OR=1.18,95%CI 1.01~1.37,P=0.039)was the independent risk factor of MACCE after drug eluting stenting in CAD patients.The risk of MACCE after drug eluting stenting in CAD patients significantly increased when the Fg level was>3.27 g/L.Conclusion:High Fg level is the independent risk factor of MACCE after drug eluting stenting in CAD patients.

关 键 词：冠状动脉疾病 药物洗脱支架 影响因素分析 

分 类 号：R541.4[医药卫生—心血管疾病]