心肌梗死患者CRP、白细胞介素-6水平与心功能的相关性  

Association of CRP and interleukin-6 levels with cardiac function in patients with myocardial infarction

作　　者：赵智敏 鹿砚 王婉擎 李伟杨 ZHAO Zhi-min;LU Yan;WANG Wan-qing;LI Wei-yang(Department of Cardiovascular Medicine,Sanya Harbin Medical University Hongsen Hospital Co.,Ltd,Sanya,Hainan,572022,China)

机构地区：[1]三亚哈尔滨医科大学鸿森医院有限公司心内科,海南三亚572022 [2]吉林省吉林市磐石市医院儿科药房

出　　处：《心血管康复医学杂志》2025年第2期250-255,共6页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探究心肌梗死(MI)患者C反应蛋白(CRP)、白细胞介素-6(IL-6)水平及其与心功能的相关性。方法:选择2020年1月-2022年12月三亚哈尔滨医科大学鸿森医院有限公司收治的140例MI患者为MI组,根据冠状动脉狭窄程度分为轻度组62例、中度组41例、重度组37例,另选择同期75例体检健康者为对照组。采用全自动生化分析仪检测血清CRP、IL-6、心肌肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)水平,超声心动图评估左室射血分数(LVEF)。比较MI组与对照组,不同冠脉病变程度MI患者的上述指标。采用Pearson/Spearman相关性分析MI患者血清CRP、IL-6水平与Gensini评分、cTnI、CK-MB水平、LVEF的相关性,受试者工作特征(ROC)曲线分析血清CRP、IL-6水平对MI的诊断价值。结果:与对照组比较,MI组血清CRP、IL-6、cTnI、CK-MB水平显著升高,LVEF显著降低(P均<0.001)。轻度组、中度组、重度组血清CRP、IL-6、cTnI、CK-MB水平依次显著升高,LVEF依次显著降低(P均<0.01)。Pearson/Spearman相关性分析显示,MI患者血清CRP、IL-6水平与Gensini评分、cTnI水平、CK-MB水平呈正相关(r=0.496~0.646,P均<0.001),与LVEF呈负相关(r=-0.530、-0.572,P均<0.001)。ROC曲线显示,CRP联合IL-6检测[曲线下面积(AUC)=0.856,95%CI 0.802~0.900]诊断MI的价值要显著高于CRP(AUC=0.770,95%CI 0.708~0.824)、IL-6(AUC=0.793,95%CI 0.733~0.845)单独检测(Z=3.295、2.877,P均<0.01)。结论:MI患者血清CRP、IL-6水平升高,与冠状动脉病变程度增加、心功能降低密切相关。Objective:To investigate the levels of C reactive protein(CRP)and interleukin(IL)-6 in patients with myocardial infarction(MI)and their association with cardiac function.Methods:We enrolled 140 MI patients admitted to Sanya Harbin Medical University Hongsen Hospital Co.,Ltd between January 2020 and December 2022,as MI group.According to coronary stenotic severity,they were divided into mild group(n=62),moderate group(n=41)and severe group(n=37),and 75 healthy individuals who underwent physical examination simultaneously were selected as control group.Serum CRP,IL-6,cardiac troponin I(cTnI)and creatine kinase isoenzyme MB(CK-MB)levels were measured by automatic biochemical analyzer,and left ventricular ejection fraction(LVEF)was assessed by echocardiography.Above-mentioned indexes were compared between MI group and control group,and among groups of different coronary disease severity.Pearson/Spearman correlation was used to analyze the association of serum CRP and IL-6 levels with Gensini score,cTnI,CK-MB levels,and LVEF in MI patients.Diagnostic value of serum CRP and IL-6 levels for MI was analyzed by receiver operating characteristic(ROC)curve.Results:Compared with participants in control group,those in MI group had significant higher serum CRP,IL-6,cTnI and CK-MB,and significant lower LVEF(P<0.001 all).Serum CRP,IL-6,cTnI and CK-MB levels significantly increased,and LVEF significant decreased in the order of mild group,moderate group and severe group(P<0.01 all).Pearson/Spearman correlation analysis showed that serum CRP and IL-6 levels were positively correlated with Gensini score,cTnI,and CK-MB levels(r=0.496~0.646,P<0.001 all),and negatively correlated with LVEF(r=-0.530,-0.572,P<0.001 all)in MI patients.ROC curve showed that the area under the curve(AUC)of CRP combined IL-6 diagnosing MI was 0.856(95%CI 0.802~0.900),which was significantly higher than those of CRP(AUC=0.770,95%CI 0.708~0.824)and IL-6(AUC=0.793,95%CI 0.733~0.845)alone(Z=3.295,2.877,P<0.01 all).Conclusion:Serum CRP and IL-6 levels rise in MI

关 键 词：心肌梗死 C反应蛋白质 白细胞介素6 

分 类 号：R542.22[医药卫生—心血管疾病]