法罗培南钠颗粒联合阿奇霉素干混悬剂对化脓性扁桃体炎患儿的应用效果及对T淋巴细胞亚群及相关因子影响  

The Application Effect of Faropenem Sodium Granules Combined with Azithromycin Dry Suspension on Children with Purulent Tonsillitis and Its Impact on T Lymphocyte Subsets and Related Factors

作　　者：潘华宝 乐楠 于锦 周圆 孙雯 PAN Hua-bao;YUE Nan;YU Jin;ZHOU Yuan;SUN Wen(Department of Pharmacy,Yancheng First Hospital Affiliated to Nanjing University Medical College/Yancheng NO.1 People's Hospital,Yancheng,Jiangsu,224000,China)

机构地区：[1]南京大学医学院附属盐城第一医院/盐城市第一人民医院药学部,江苏盐城224000

出　　处：《现代生物医学进展》2025年第6期1031-1038,共8页Progress in Modern Biomedicine

基　　金：江苏省药学会-恒瑞医院药学基金科研项目(H202148)。

摘　　要：目的:探讨法罗培南钠颗粒联合阿奇霉素干混悬剂对化脓性扁桃体炎患儿的应用效果及对T淋巴细胞亚群及相关因子影响。方法:前瞻性选取2022年3月至2024年3月的96例化脓性扁桃体炎患儿,应用抽签法分为对照组与研究组,各48例。给予对照组患儿阿奇霉素干混悬剂治疗,给予研究组患儿法罗培南钠颗粒联合阿奇霉素干混悬剂治疗。两组均治疗5 d时间后比较其临床疗效,症状与体征改善时间,治疗前、治疗后5 d T淋巴细胞亚群及其相关因子变化,并比较两组用药安全性情况。结果:研究组总有效率95.83%高于对照组79.17%(P<0.05);研究组白细胞计数正常时间、退热时间、脓肿消失时间、咽痛消失时间均短于对照组(P<0.05);治疗后,研究组与对照组CD4^(+)、CD3^(+)、CD4^(+)/CD8^(+)均升高,CD8^(+)降低,研究组与对照组比较有差异(P<0.05);治疗后,研究组与对照组IL-8、TNF-α、IFN-γ、IL-4均降低,研究组低于对照组,IL-13、IL-10升高,研究组高于对照组(P<0.05);两组均无严重不良反应发生,其中对照组患者1例出现上腹部不适,1例皮疹。研究组1例出现恶心、1例乏力、1例肝功能异常,两组患儿不良反应均为轻微,停药后消失,研究组不良反应发生率6.25%(3/48)与对照组4.17%(2/48)对比无明显差异(P>0.05)。结论:法罗培南钠颗粒联合阿奇霉素干混悬剂治疗化脓性扁桃体炎疗效显著,可缩短患儿症状持续时间,改善免疫功能,减轻机体炎症反应,其安全性较高。Objective:To investigate the application effect of Faropenem Sodium Granules combined with Azithromycin Dry Suspension on children with purulent tonsillitis and its impact on T lymphocyte subsets and related factors.Methods:96 children with suppurative tonsillitis from March 2022 to March 2024 were prospectively selected and divided into a matched group and a study group using a lottery method,with 48 cases in each group.Patients in the matched group were treated with azithromycin dry suspension,while those in the study group were treated with Faropenem sodium granules combined with azithromycin dry suspension.Compare the clinical efficacy,improvement time of symptoms and signs,changes in T lymphocyte subsets and related factors before and Post-treatment for 5 days in both groups,and compare the safety of medication between the two groups.Results:The total effective rate of the research group was 95.83%,which was higher than the matched group's 79.17%(P<0.05);The normal time of white blood cell count,fever reduction time,disappearance time of abscess,and disappearance time of sore throat in the research group were all shorter than those in the matched group(P<0.05);Post-treatment,CD4^(+),CD3^(+),CD4^(+)/CD8^(+)increased and CD8^(+)decreased between the study and control group,unlike comparing the study group and the matched group(P<0.05);Post-treatment,the levels of IL-8,TNF-α,IFN-γ,and IL-4 in the study group and the matched group decreased,while the levels of IL-13 and IL-10 increased.The levels of IL-13 and IL-10 in the study group were higher than those in the matched group(P<0.05);There were no serious adverse reactions in either group,with one patient in the matched group experiencing upper abdominal discomfort and one patient experiencing a rash.There was one case of nausea,one case of fatigue,and one case of liver dysfunction in the study group.The adverse reactions in both groups were mild and disappeared after discontinuation of medication.The incidence of adverse reactions in the study group was 6.25

关 键 词：法罗培南钠颗粒 阿奇霉素干混悬剂 化脓性扁桃体炎 T淋巴细胞亚群 炎症因子 安全性 

分 类 号：R3[医药卫生—基础医学] R766.18