复方玄黄利咽口服液水提工艺优选  

Optimization of Water Extraction Process for Compound Xuanhuang Liyan Oral Liquid

作　　者：王淋丽 丁家昱 韩宪忠 WANG Linli;DING Jiayu;HAN Xianzhong(Qianjiang Central Hospital of Chongqing,Chongqing,China 409099;Chongqing General Hospital,Chongqing University·Chongqing General Hospital,Chongqing,China 400014)

机构地区：[1]重庆市黔江中心医院,重庆409099 [2]重庆大学附属人民医院·重庆市人民医院,重庆400014

出　　处：《中国药业》2025年第8期61-64,共4页China Pharmaceuticals

基　　金：重庆市重点实验室开发课题项目[2020-2-7]。

摘　　要：目的优化复方玄黄利咽口服液的水提工艺。方法以乙醇体积分数、乙醇用量、提取时间、提取次数为考察因素,哈巴俄苷含量及收膏率的综合评分为考察指标,采用L_(9)(3^(4))正交试验法优选制剂的水提工艺,并验证。结果优选工艺为,采用药材8倍量(首次用10倍量)的60%乙醇,热回流提取2次,每次1.5 h;验证试验中3批次样品哈巴俄苷平均含量为222.52μg/mL,平均收膏率为24.22%。结论优选的水提工艺科学、稳定、可行,可用于复方玄黄利咽口服液中有效成分的提取。Objective To optimize the water extraction process for Compound Xuanhuang liyan oral liquid.Method With as the evaluation index,the L_(9)(3^(4))orthogonal test was used to optimize the water extraction process of Compound Xuanhuang Liyan Oral Liquid with ethanol volume fraction,ethanol dosage,extraction time and extraction times as the investigation factors,and validation test was carried out.Results The optimal water extraction process was as follows:adding eight times the amount of 60% ethanol(ten times the amount used for the first time),hot reflux extracting twice,each time for 1.5 hours.In the validation test,the average content of harpagoside in the three batches of samples was 222.52μg/mL,and the average paste yield was 24.22%.Conclusion The optimal water extraction process is scientific,stable,feasible,and can be used for extracting effective ingredients from Compound Xuanhuang Liyan Oral Liquid.

关 键 词：正交试验法 提取工艺 优化 复方玄黄利咽口服液 

分 类 号：R943[医药卫生—药剂学]