司库奇尤单抗联合卡泊三醇软膏治疗中重度斑块状银屑病临床观察  

Clinical Observation of Botriol Ointment Combined with Sikuximab Injection in the Treatment of Moderate to Severe Plaque Psoriasis

作　　者：马涛[1] 陆延娜 徐亚楠[1] MA Tao;LU Yanna;XU Yanan(Yan'an People's Hospital,Yan'an,Shaanxi,China 716000)

机构地区：[1]陕西省延安市人民医院,陕西延安716000

出　　处：《中国药业》2025年第8期91-93,共3页China Pharmaceuticals

基　　金：陕西省延安市科学技术研究发展计划项目[2018KS-27]。

摘　　要：目的探讨司库奇尤单抗联合卡泊三醇软膏治疗中重度斑块状银屑病的临床疗效。方法选取医院2022年9月至2023年9月收治的中重度斑块状银屑病患者118例,按随机数字表法分为对照组和观察组,各59例。两组患者均予卡泊三醇软膏涂抹,观察组患者加予司库奇尤单抗注射液皮下注射。两组均持续治疗12周。结果与治疗前比较,两组患者治疗后的银屑病严重程度评分、皮肤病生活质量指数评分均显著降低(P<0.05),焦虑自评量表、抑郁自评量表评分均显著降低(P<0.05),皮脂含量、角质层含水量均显著升高(P<0.05),且观察组患者上述指标改善程度更显著(P<0.05)。观察组不良反应发生率为5.08%,显著低于对照组的16.95%(P<0.05)。结论卡泊三醇软膏联合卡泊三醇软膏治疗中重度斑块状银屑病,可减轻患者皮损严重程度,提高生活质量,改善其不良心理情绪和皮肤屏障功能。Objective To investigate the clinical efficacy of secukinumab combined with calcipotriol ointment in the treatment of moderate to severe plaque psoriasis.Methods A total of 118 patients with moderate to severe plaque psoriasis admitted to the hospital from September 2022 to September 2023 were selected.They were divided into a control group and an observation group according to the random number table method,with 59 patients in each group.Both groups were applied with calcipotriol ointment,and the observation group was additionally given subcutaneous injection of Secukinumab Injection.Both groups were treated continuously for 12 weeks.Results Compared with those before treatment,the Psoriasis Area and Severity Index(PASI)scores and Dermatology Life Quality Index(DLQI)scores of the patients in both groups were significantly decreased after treatment(P<0.05),and the scores of Self-Rating Anxiety Scale(SAS)and Self-Rating Depression Scale(SDS)were also significantly decreased(P<0.05).The sebum content and the water content of the stratum corneum were significantly increased(P<0.05),and the improvement of the above indicators in the observation group was more significant(P<0.05).The incidence of adverse reactions in the observation group was 5.08%,which was significantly lower than 16.95%in the control group(P<0.05).Conclusion Calcipotriol ointment combined with secukinumab injection in the treatment of moderate to severe plaque psoriasis can reduce the severity of skin lesions in patients,improve their quality of life,and ameliorate their adverse psychological emotions and skin barrier function.

关 键 词：中重度 斑块状银屑病 司库奇尤单抗注射液 卡泊三醇软膏 生活质量 负性情绪 

分 类 号：R969.4[医药卫生—药理学]