脑血疏口服液佐治高血压脑出血临床评价  

Clinical Evaluation of Naoxueshu Oral Liquid in the Adjuvant Treatment of Hypertensive Intracerebral Hemorrhage

作　　者：齐洪武 刘岩松 曾维俊 郭洪均 郝紫建 QI Hongwu;LIU Yansong;ZENG Weijun;GUO Hongjun;HAO Zijian(The 980th Hospital of the Joint Service Support Force of the Chinese People's Liberation Army,Shijiazhuang,Hebei,China 050082)

机构地区：[1]中国人民解放军联勤保障部队第九八〇医院,河北石家庄050082

出　　处：《中国药业》2025年第8期94-98,共5页China Pharmaceuticals

基　　金：河北省石家庄市科学技术研究与发展计划项目[201200753]。

摘　　要：目的探讨脑血疏口服液佐治高血压脑出血(HICH)的临床疗效,以及对患者血清高迁移率族蛋白(HMGB-1)、凝溶胶蛋白(GSN)、神经元特异性烯醇化酶(NSE)水平和患者预后的影响。方法选取医院2021年1月至2023年6月收治的高血压脑出血(HICH)患者104例,按随机数字表法分为对照组和观察组,各52例。两组患者均予常规对症支持治疗,观察组患者加服脑血疏口服液,均治疗4周。比较两组患者血清因子HMGB-1、GSN、NSE水平,美国国立卫生研究院卒中量表(NIHSS)、格拉斯哥预后量表(GOS)评分,并对患者3个因子水平与2个量表评分行Pearson相关性分析;比较两组患者的临床疗效,并比较观察组不同疗效患者血清中3个因子水平;以受试者工作曲线(ROC)分析观察组患者血清3个因子水平对其临床疗效的诊断价值。结果两组患者治疗后的血清HMGB-1、NSE水平及NIHSS评分均明显降低,GSN水平及GOS评分均明显升高,且观察组均明显优于对照组(P<0.05);观察组患者HMGB-1、NSE水平与NIHSS评分呈正相关,与GOS评分呈负相关(P<0.05);GSN水平与NIHSS评分呈负相关,与GOS评分呈正相关(P<0.05);观察组总有效率为86.54%,明显高于对照组的71.15%(P<0.05);与治疗无效患者比较,治愈、显效、有效患者血清内HMGB-1、NSE水平均明显降低,GSN水平明显升高(P<0.05),且以治愈患者变化幅度最大。血清3个因子水平诊断临床疗效的灵敏度、特异度接近且均大于70%,联合诊断时更高。结论血清3个因子水平对脑血疏口服液临床疗效具有较高诊断价值,灵敏度、特异度均较高,HMGB-1、GSN、NSE三者单独检测诊断效能相似,联合检测体现出最高诊断价值(P<0.05)。脑血疏口服液可明显改善HICH患者神经功能缺损程度,提高患者临床疗效、改善预后,究其原因可能与降低患者血清HMGB-1、NSE及提升GSN水平有关。Objective To investigate the clinical efficacy of Naoxueshu Oral Liquid as an adjuvant therapy for hypertensive intracerebral hemorrhage(HICH),as well as its effects on serum levels of high-mobility group box-1 protein(HMGB-1),gelsolin(GSN),neuron-specific enolase(NSE)and patient prognosis.Methods A total of 104 HICH patients admitted to the hospital from January 2021 to June 2023 were selected and randomly divided into a control group and an observation group,with 52 patients in each group.Both groups received conventional symptomatic and supportive treatment,while the observation group was additionally administered Naoxueshu Oral Liquid for 4 weeks.Serum levels of HMGB-1,GSN,and NSE,as well as National Institutes of Health Stroke Scale(NIHSS)and Glasgow Outcome Scale(GOS)scores were compared between the two groups.Pearson correlation analysis was performed to assess the relationship between the three factor levels and the two scale scores.Clinical efficacy was compared between the two groups,and serum levels of the three factors were analyzed in patients with different treatment outcomes in the observation group.Receiver operating characteristic curve(ROC)analysis was used to evaluate the diagnostic value of the three serum factors for clinical efficacy in the observation group.Results After treatment,serum HMGB-1 and NSE levels as well as NIHSS scores significantly decreased,while GSN levels and GOS scores significantly increased in both two groups,and the observation group all significantly better than the control group(P<0.05).In the observation group,the levels of HMGB-1 and NSE were positively correlated with NIHSS score and negatively correlated with GOS score(P<0.05),while GSN level was negatively correlated with NIHSS score and positively correlated with GOS score(P<0.05).The total effective rate in the observation group was 86.54%,which was significantly higher than the 71.15% in the control group(P<0.05).Compared with the patients with ineffective treatment,the levels of HMGB-1 and NSE in the serum of

关 键 词：高血压脑出血 脑血疏口服液 高迁移率族蛋白 凝溶胶蛋白 神经元特异性烯醇化酶 临床疗效 相关性 诊断价值 

分 类 号：R969.4[医药卫生—药理学] R544.1[医药卫生—药学]