“互联网+”药学服务对高血压患者干预效果的Meta分析  

Meta-Analysis of the Intervention Effect of"Internet+"Pharmaceutical Care on Patients with Hypertension

作　　者：凌雪梅[1] 田伟[2] LING Xuemei;TIAN Wei(West China Hospital,Sichuan University,Chengdu,Sichuan,China 610041;Sichuan Academy of Medical Sciences,Sichuan Provincial People's Hospital,Chengdu,Sichuan,China 610072)

机构地区：[1]四川大学华西医院,四川成都610041 [2]四川省医学科学院·四川省人民医院,四川成都610072

出　　处：《中国药业》2025年第8期114-119,共6页China Pharmaceuticals

基　　金：四川省干部保健科研课题[川干研2020-104]。

摘　　要：目的系统评价“互联网+”药学服务对高血压患者的干预效果。方法计算机检索Medline、Embase、The Cochrane Library、Web of Science、中国知网、万方、维普、中国生物医学文献服务系统,检索时限均为各数据库自建库起至2024年5月,根据Cochrane系统评价法对纳入的随机对照试验进行方法学质量评价,并用RevMan 5.3软件进行Meta分析。结果共纳入13个随机对照试验(RCT),文献质量总体较差。共包括患者2103例,其中试验组(“互联网+”药学服务+常规干预)1050例,对照组(常规治疗+其他干预)1053例。Meta分析结果显示,干预组血压达标率[OR=2.90,95%CI(2.32,3.64),P<0.00001],收缩压变化情况[MD=-10.12,95%CI(-16.04,-4.21),P=0.0008],舒张压变化情况[MD=-6.41,95%CI(-9.43,-3.40),P<0.0001],总用药依从性[OR=5.72,95%CI(3.77,8.69),P<0.00001],总用药满意度[OR=3.76,95%CI(1.58,8.94),P=0.003]、药品不良反应发生率[RR=0.44,95%CI(0.33,0.58),P<0.00001]均优于对照组。结论“互联网+”药学服务对高血压患者各结局指标干预效果较好。但本研究纳入研究质量较低,该结论尚需进一步验证。Objective To systematically evaluate the intervention effect of"Internet+"pharmaceutical care on patients with hypertension.Methods Medline,Embase,The Cochrane Library,Web of Science,CNKI,WanFang,VIP and SinoMed were searched by computer from the establishment of each database to May 2024.The methodological quality of the included randomized controlled trials was evaluated according to the Cochrane systematic review method,and Meta-analysis was performed using RevMan5.3 software.Results A total of 13 randomized controlled trials(RCTs)were included,and the quality of the literature was generally poor.A total of 2103 patients were included,including 1050 cases in the experimental group("Internet+"pharmaceutical care+routine intervention)and 1053 cases in the control group(routine treatment+other interventions).The results of Meta-analysis showed that the control rate of blood pressure in the intervention group[OR=2.90,95%CI(2.32,3.64),P<0.00001],the change of systolic blood pressure[MD=-10.12,95%CI(-16.04,-4.21),P=0.0008];the changes of diastolic blood pressure[MD=-6.41,95%CI(-9.43,-3.40),P<0.0001],total medication compliance[OR=5.72,95%CI(3.77,8.69),P<0.00001],total medication satisfaction[OR=3.76,95%CI(1.58,8.94),P=0.003]and the incidence of adverse drug reactions[RR=0.44,95%CI(0.33,0.58),P<0.00001]in the observation group were better than those in the control group.Conclusion"Internet+"pharmaceutical care has a good effect on the intervention of outcome indicators in patients with hypertension.However,the quality of the included studies in this study is low,and the conclusion needs to be further verified.

关 键 词：“互联网+” 药学服务 高血压 META分析 

分 类 号：R969.3[医药卫生—药理学]