中药调控PI3K/Akt信号通路促进慢性创面愈合的研究进展  

Research progress of traditional Chinese medicine regulating PI3K/Akt signaling pathway to promote chronic wound healing

作　　者：朱振辉 李志 冷羽 蔡涛 申学发 向先雪 黄永新 ZHU Zhenhui;LI Zhi;LENG Yu;CAI Tao;SHEN Xuefa;XIANG Xianxue;HUANG Yongxin(First Clinical Medical College,Guizhou University of Traditional Chinese Medicine,Guiyang 550002,China;Dept.of Anorectal Surgery,the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550001,China)

机构地区：[1]贵州中医药大学第一临床医学院,贵阳550002 [2]贵州中医药大学第一附属医院肛肠科,贵阳550001

出　　处：《中国药房》2025年第8期1019-1024,共6页China Pharmacy

基　　金：国家自然科学基金项目(No.82160909);贵州省基础研究计划(自然科学)面上项目(No.黔科合基础MS〔2025〕135);贵州省科技计划项目(No.黔科合基础-ZK〔2023〕一般438);贵州省卫生健康委科学技术基金项目(No.gzwkj2023-169);贵州省中医药管理局中医药、民族医药科学技术研究项目(No.QZYY-2023-004)。

摘　　要：慢性创面愈合的发病机制十分复杂,这类创伤通常伴随着较长的病程和较大的治疗难度,导致愈合困难,严重影响患者的生活质量。中药有效成分、药对及复方在治疗慢性创面愈合上具有独特优势。磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/Akt)信号通路通过调控细胞凋亡、血管生成及炎症反应等一系列生物学过程在治疗慢性创面愈合方面极其关键。本文对中药调控PI3K/Akt信号通路促进慢性创面愈合的相关研究进行综述,发现中药有效成分(如京尼平苷、黄芪甲苷、人参皂苷等)及复方(如冲和膏、黄连膏、湿润烧伤膏等)主要通过激活PI3K/Akt信号通路来降低炎症反应、促进血管生成、调节细胞自噬,进而加速创面愈合;同时也有少数中药如药对(如黄芪-红花)、复方(如象皮生肌膏)通过抑制该信号通路发挥抗炎作用,促进创面愈合。The pathogenesis of chronic wound healing is complex.It is often difficult to heal due to a long course of disease,difficulty in treatment,and it seriously affects the quality of life in patients.The active ingredients,couplet medicinals,and compound formulas of traditional Chinese medicine(TCM)possess unique advantages in the treatment of chronic wound healing.The phosphatidylinositol 3-kinase/protein kinase B(PI3K/Akt)signaling pathway is extremely critical in the treatment of chronic wound healing by regulating a series of biological processes,including cell apoptosis,angiogenesis,and inflammatory responses.This article reviews the relevant research on the regulation of the PI3K/Akt signaling pathway by TCM to promote chronic wound healing.It has been found that the active ingredients of TCM(such as geniposide,astragaloside,and ginsenosides,etc.),and compound formulas(such as Chonghe ointment,Huanglian ointment,Shirun shaoshang ointment,etc.)mainly reduce inflammatory responses,promote angiogenesis,regulate cell autophagy,and accelerate wound healing by activating the PI3K/Akt signaling pathway;at the same time,there are also a few couplet medicinals(such as Huangqi-Honghua)and compound formulas(such as Xiangpi Shengji ointment)that exert anti-inflammatory effects by inhibiting this signaling pathway,to promote wound healing.

关 键 词：中药 活性成分 药对 复方 慢性创面愈合 PI3K/AKT信号通路 机制 

分 类 号：R965[医药卫生—药理学]