基于石墨烯-超表面THz生物传感器的 痕量氨基酸高精度检测  

High-Precision Detection of Trace Amino Acids Based on Graphene-Metasurface THz Biosensors

作　　者：田汇涵 张永刚[1] 梁兰菊 姚海云 王子群 TIAN Huihan;ZHANG Yonggang;LIANG Lanju;YAO Haiyun;WANG Ziqun(School of Electrical and Information Engineering,Anhui University of Science and Technology,Huainan 232001,China;School of Opto-Electronic Engineering,Zaozhuang University,Zaozhuang 277160,China)

机构地区：[1]安徽理工大学电气与信息工程学院,安徽淮南232001 [2]枣庄学院光电工程学院,山东枣庄277160

出　　处：《枣庄学院学报》2025年第2期37-44,91,共9页Journal of Zaozhuang University

基　　金：国家自然科学基金(62375235、62201496、62471431);山东省自然科学基金(ZR2023MF107、ZR202102180769、ZR2022QF054、ZR2021MF014);山东省高校青创科技计划(2023KJ283);山东省泰山学者计划(tsqn201909150);山东省高校青年创业人才引进项目的资助。

摘　　要：提出一种基于石墨烯与周期性金属微结构谐振器相结合的超表面生物传感器,并利用该传感器对L-精氨酸(L-Arg)和D-酪氨酸(D-Tyr)进行了透射光谱检测。结果表明,该传感器对L-Arg和D-Tyr的检测限(LOD)均达到了200 fg/mL,表现出很高的检测精度。石墨烯的引入显著提升了传感器的检测灵敏度,待测物质通过调控石墨烯狄拉克点附近的费米能级(E F)实现灵敏响应。通过引入小波变化对测得信号进行分析,并利用二维小波系数强度图有效识别不同浓度的L-Arg和D-Tyr。基于石墨烯和超表面结合的复合结构生物传感,为进一步提升THz生物传感器的检测精度提供了新的路径。An ultra-surface biosensor based on the combination of graphene and periodic metal microstructured resonators was proposed and utilized for the transmission spectroscopic detection of L-arginine(L-Arg)and D-tyrosine(D-Tyr).The results showed that the sensor exhibited high detection accuracy with a limit of detection(LOD)of 200 fg/mL for both L-Arg and D-Tyr.The introduction of graphene significantly enhanced the detection sensitivity of the sensor,and the substances to be measured were able to achieve a sensitive response by modulating the Fermi energy level(E F)near the Dirac point of graphene.The measured signals were analyzed by introducing wavelet variations,and the two-dimensional wavelet coefficient intensity maps were used to effectively identify different concentrations of L-Arg and D-Tyr.Composite structure biosensing based on the combination of graphene and hypersurfaces provides a new pathway to further enhance the detection accuracy of THz biosensor.

关 键 词：超表面 石墨烯 传感器 太赫兹 

分 类 号：O431.1[机械工程—光学工程]