医用高熵合金植入物研究进展  

Research progress on medical high-entropy alloy implants

作　　者：王宇琦 王银晨 毕晓阳 柳志泽 董红刚[1] 张爽[2] 李鹏[1] WANG Yuqi;WANG Yinchen;BI Xiaoyang;LIU Zhize;DONG Honggang;ZHANG Shuang;LI Peng(School of Materials Science and Engineering,Dalian University of Technology,Dalian 116024,Liaoning,China;Department of Orthopedic Surgery,Central Hospital of Dalian University of Technology,Dalian Municipal Central Hospital,Dalian 116021,Liaoning,China)

机构地区：[1]大连理工大学材料科学与工程学院,辽宁大连116024 [2]大连理工大学附属中心医院(大连市中心医院)骨外科,辽宁大连116021

出　　处：《金属加工(热加工)》2025年第4期126-141,150,共17页MW Metal Forming

基　　金：中央高校基本科研业务费资助(DUT24ZD202);大连市生命健康领域指导计划项目(2023ZXYG29);大连市中心医院“省级重点专科”院内科研自主立项项目(2023SZ022)。

摘　　要：因创伤、感染、肿瘤等原因造成的骨折和骨缺损问题一直广受关注。尽管人体骨组织有一定的再生和修复能力,但单纯依靠骨再生难以完成骨缺损的修复。当下TC4钛合金、不锈钢和铬钼合金等传统医用材料与人体细胞相容性较低,因此迫切需要开发出力学性能优良、生物相容性适宜的新型生物材料来解决长期植入引起的应力屏蔽和细胞相容性差等不良反应的共同难题。由于存在鸡尾酒效应,高熵合金具有可适应性调节的力学性能和良好的生物相容性,已被广泛应用至新型医用植入物材料。从医用高熵合金元素选择、力学性能、生物性能及耐蚀性4个方面探讨了目前医用高熵合金植入物材料的研究热点及进展,并展望了未来医用高熵合金的发展趋势,为后续新型医用高熵合金植入物材料的研究提供方法、思路和理论支撑。The difficulties of fractures and bone defects due to injury,infection and tumor have been widely concerned.Although human bone tissues have certain regenerative and reparative abilities,it is difficult to complete the repair of bone defects merely by relying on bone regeneration.The compatibility of the current traditional medical materials with human cells is poor,and it is imperative to develop new biomaterials with excellent mechanical properties and suitable biocompatibility to solve the negative reactions caused by long-term insertion.High-entropy alloys with adaptable regulated mechanical properties and sound biocompatibility have been widely applied to new medical implant materials.The study investigates the current research hotspots and the progress of medical high-entropy alloy implant materials from medical high-entropy alloy design,element selection,mechanical properties and biological properties.It is promising to provide the methodological reference and theoretical support for the subsequent research of new medical high-entropy alloy implant materials.

关 键 词：医用高熵合金 力学性能 生物相容性 元素选择 

分 类 号：TG146.2[一般工业技术—材料科学与工程] TG146.23[金属学及工艺—金属材料]