氨基酮戊酸光动力疗法治疗硬化萎缩性苔藓的疗效观察  

Observation of efficacy of aminoketovaleric acid photodynamic therapy on lichen sclerosus et atrophicus

作　　者：赵越[1] 郭梦月 刘伟霞 宁小丽 赵丽君[1] 梁艳玲 ZHAO Yue;GUO Mengyue;LIU Weixia;NING Xiaoli;ZHAO Lijun;LIANG Yanling(Department of Dermatology,Heping Hospital Afiliated to Changzhi Medical College,Changzhi 046000,China;Department of Dermatology,Changzhi People's Hospital,Changzhi 046000,China;Department of Blood Transfusion,Heping Hospital Affiliated to Changzhi Medical College,Changzhi 046000,China)

机构地区：[1]长治医学院附属和平医院皮肤科,山西长治046000 [2]长治市人民医院皮肤科,山西长治046000 [3]长治医学院附属和平医院输血科,山西长治046000

出　　处：《临床皮肤科杂志》2025年第4期208-211,共4页Journal of Clinical Dermatology

摘　　要：目的:观察氨基酮戊酸光动力疗法(ALA-PDT)治疗硬化萎缩性苔藓的临床效果。方法:回顾性分析2020年8月—2023年8月于长治医学院附属和平医院皮肤科门诊诊断为硬化萎缩性苔藓的32例患者资料。所有患者每周接受1次ALAPDT治疗,整个疗程通常持续4~6次,于治疗的第0、2、4、6、8周分别记录皮损评分和治疗过程中的不良反应。采用Cattaneo临床症状和体征评分评估疗效。结果:本研究对32例硬化萎缩性苔藓患者的疗效进行了评估。治疗前Cattaneo临床症状和体征总分均值为(10.53±1.02)分,治疗后第2、4、6、8周分别为(9.50±1.32)、(7.19±1.23)、(5.84±1.25)和(4.16±1.14)分,均较治疗前降低,差异均有统计学意义(P<0.05)。与治疗前比较,治疗后第8周患者皮损瘙痒程度、皮肤弹性、皮肤颜色和病变范围均有明显改善,且差异均有统计学意义(P<0.05)。治疗8周后患者的治疗总体有效率为71.87%。结论:ALA-PDT治疗硬化萎缩性苔藓效果显著,可有效改善患者症状。Objective:To explore the clinical efficacy of aminoketovalerate photodynamic therapy(ALA-PDT)in the treatment of lichen sclerosus et atrophicus.Method:Thirty-two patients diagnosed with lichen sclerosus et atrophicus in our outpatient department from August 2020 to August 2023 were included in this retrospective study.Each patient received ALA-PDT treatment once a week,the entire course usually lasted 4-6 times,and follow-up was arranged at O,2,4,6 and 8 weeks of treatment.The score of the lesions and adverse reactions after treatment were recorded,and efficacy was evaluated to assess the effectiveness of the treatment and the improvement of the patient's condition.Results:This study evaluated the efficacy of ALA-PDT in the treatment of 32 patients with lichen sclerosus et atrophicus.The total score for the symptom and sign was 10.53±1.02 before treatment,and was 9.50±1.32,7.19±1.23,5.84±1.25 and 4.16±1.14 at 2,4,6 and 8 weeks after treatment,respectively.The total scores for the symptom and sign after treatment were significantly lower than those before treatment,and the differences were statistically significant(P<0.05).Other indicators to evaluate the treatment effect,including itch score,skin elasticity,skin color and the areas of lesional involvement,showed significant improvement at 8th week after treatment,com-pared with that before treatment,and the differences were statistically significant(P<0.05).After treatment,32 patients achieved an overall response rate of 71.87%.Conclusion:ALA-PDT is effective in the treatment of lichen sclerosus et atrophicus;it has been proved to improve the patient's symptoms.

关 键 词：氨基酮戊酸 光动力疗法 硬化萎缩性苔藓 

分 类 号：R758.6[医药卫生—皮肤病学与性病学]