泛发性间质性环状肉芽肿并文献复习  

Generalized interstitial granuloma annulare:a case report and literature review

作　　者：王金容 杨雪松[1] 叶建州[1] 张佩莲 WANG Jinrong;YANG Xuesong;YE Jianzhou;ZHANG Peilian(Department of Dermatology,Yunnan Dermatology Hospital of Traditional Chinese Medicine,Yunnan Provincial Hospital of Traditional Chinese Medicine,Kunming 650021,China)

机构地区：[1]云南省中医医院、云南省中医皮肤病专科医院皮肤科,云南昆明650021

出　　处：《临床皮肤科杂志》2025年第4期228-230,共3页Journal of Clinical Dermatology

基　　金：云南省高层次中医药后备人才培养项目(第二批)(云财社[2024]103号)资助项目。

摘　　要：报告1例泛发性间质性环状肉芽肿。患者男,43岁。皮肤科检查:躯干和四肢泛发大小不一的环状红斑块、丘疹,边缘隆起,颜色较深,中央颜色浅,部分皮损融合。皮损组织病理检查:真皮层胶原纤维束间散在分布组织细胞和少量多核巨细胞,胶原纤维局灶性坏死,血管周围中等量淋巴细胞浸润。免疫组化:CD68和CD163阳性,阿辛蓝染色阳性。诊断:泛发性间质性环状肉芽肿。治疗:本例患者对环孢素A和羟氯喹治疗不敏感,但经泼尼松(30 mg/d)治疗后皮损消退。A case of generalized interstitial granuloma annulare is reported.A 43-year-old male presented with widespread,annular erythematous papule and plaques involving the whole body.Physical examination showed annular,erythematous patch-es and papules of variable sizes on the trunk and limbs,with dark,elevated border and central clearing.Some lesions joined into one.Histopathological examination of skin lesions showed a histiocytic infiltrate with scattered multinucleated giant cells and degenerated collagen in the dermis.There was a moderate perivascular lymphocyte infiltrate.Immunohistochemistry showed that CD68,CD163 and alcian blue staining were positive.A diagnosis of generalized interstitial granuloma annulare was made.The patient was not responsive to treatment with cyclosporine A and hydroxychloroquine.However,the lesion resolved completely after treatment with oral prednisone at a dose of 30 mg/day.

关 键 词：环状肉芽肿 间质性 泛发性 泼尼松 

分 类 号：R758.6[医药卫生—皮肤病学与性病学]