肿瘤微环境智能响应型前药自组装纳米递送系统的研究进展  

Research progress of self-assembled nano-delivery system for smart-responsive prodrugs in tumor microenvironment

作　　者：张静怡 左诗意 孙丙军 刘钿 ZHANG Jingyi;ZUO Shiyi;SUN Bingjun;LIU Tian(Wuya College of Innovation,Shenyang Pharmaceutical University,Shenyang 110016,China)

机构地区：[1]沈阳药科大学无涯创新学院,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2025年第4期295-310,共16页Journal of Shenyang Pharmaceutical University

基　　金：国家自然科学基金资助项目(82272151/82204318);中国博士后科学基金资助项目(2023MD744228);国家资助博士后研究人员计划项目(GZC20231731)。

摘　　要：纳米技术的快速发展极大地丰富了抗肿瘤药物的递送策略。传统纳米制剂通过非共价作用力包载药物,由于药物与载体材料的亲和力不足,存在载药量低和药物泄漏导致潜在毒性等问题,限制了其抗肿瘤效率和临床转化。前药自组装纳米粒具有安全性好、制备工艺简便等多重技术优势。通过对自组装前药中响应模块的合理设计,触发前药自组装纳米递送系统在肿瘤微环境中的智能激活,有望实现高效低毒的抗肿瘤治疗。本文概述了肿瘤微环境的特点及形成原因,系统总结了针对肿瘤微环境中高氧化还原电位、酸性、缺氧、酶过表达等特点的响应模块设计策略,综述了基于肿瘤微环境激活的前药自组装纳米递送系统的研究进展及未来展望。The rapid development of nanotechnology has greatly enriched the delivery strategies of antitumor drugs.However,traditional nanomedicine,which encapsulate drugs through non-covalent forces,suffer from low drug loading capacity and drug leakage leading to potential toxicity due to the insufficient affinity between the drug and the carrier material,limiting their antitumor efficiency and clinical translation.Self-assembled nanoparticles of prodrugs have multiple advantages such as good safety and easy preparation process.Through the rational design of response modules in self-assembled prodrugs,the self-assembled prodrug nano-delivery system in tumor microenvironment could be triggered intelligently,which is expected to achieve highly efficient and low-toxicity antitumor therapy.In this review,the characteristics and causes of the tumor microenvironment were outlined,and the design strategy of response module for high redox potential,acidity,hypoxia,enzyme overexpression,etc.were summarized,and the research progress of the self-assembled nano-delivery system based on the activation of tumor microenvironment was discussed,as well as the future outlook of the system.

关 键 词：肿瘤微环境 前药 自组装 纳米递药系统 

分 类 号：R94[医药卫生—药剂学]