2型糖尿病患者TyG指数与甲状腺结节的关联性  

Study on the association between triglyceride-glucose and thyroid nodules in patients with type 2 diabetes mellitus

作　　者：琚盼雨 杨富琦 周兴建 Ju Panyu;Yang Fuqi;Zhou Xingjian(Department of Endocrinology,Xiangyang No.1 People’s Hospital,Hubei University of Medicine,Xiangyang 441100,China;Department of Endocrinology,Postgraduate Union training base of Xiangyang No.1 People's Hospital,School of Medicine,Wuhan University of Science and Technology,Xiangyang 441100,China)

机构地区：[1]湖北医药学院附属襄阳市第一人民医院内分泌科,湖北襄阳441000 [2]武汉科技大学医学院襄阳市第一人民医院研究生联合培养基地内分泌科,湖北襄阳441000

出　　处：《临床荟萃》2025年第4期329-333,共5页Clinical Focus

基　　金：2024年湖北省自然科学基金创新发展联合基金项目新型污染物PPCPs致甲状腺功能紊乱的识别模型构建分子机制研究(2024AFD035)。

摘　　要：目的探讨2型糖尿病(type 2 diabetes mellitus,T2DM)患者甘油三酯-葡萄糖(triglyceride-glucose,TyG)指数与甲状腺结节(thyroid nodules,TN)的关联性。方法选取2022年1月-2023年11月于湖北医药学院附属襄阳市第一人民医院内分泌科住院治疗的T2DM患者365例,其中合并TN(研究组)223例,未合并TN(对照组)142例。获取临床资料,计算TyG指数,采用多因素logistic回归分析影响T2DM患者合并TN的独立危险因素;绘制限制性立方样条(restricted cubic spline,RCS)图直观反映TyG指数与T2DM患者TN的关系。结果研究组女性占比、年龄、空腹血糖、总胆固醇、甘油三脂、胰岛素抵抗指数和TyG指数均高于对照组(P<0.05)。多因素logistic回归分析提示,TyG指数升高是T2DM患者发生TN的独立危险因素(P<0.05)。RCS图分析结果显示,T2DM患者TyG指数与TN风险呈现线性剂量反应关系(P overll<0.001,P non-linear=0.65)。结论TyG指数是T2DM患者发生TN的独立危险因素,随着TyG指数的升高,T2DM患者中TN的发生率显著升高。Objective To investigate the correlation between triglyceride-glucose(TyG)and thyroid nodules(TNs)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 365 T2DM patients hospitalized in the Department of Endocrinology,Xiangyang First People's Hospital Affiliated to Hubei University of Medicine from January 2022 to November 2023 were selected,including 223 patients with TNs(study group)and 142 patients without TNs(control group).The clinical data were obtained,and the TyG was calculated.Multivariate logistic regression analysis was used to analyze the independent risk factors for TNs in T2DM patients.The restricted cubic spline(RCS)map was drawn to intuitively reflect the relationship between TyG and TNs in T2DM patients.Results The proportion of women,age,fasting blood glucose,total cholestero,triglyceride,insulin resistance index and TyG in the study group were significantly higher than those of the control group(P<0.05).Multivariate logistic regression analysis showed that elevated TyG was an independent risk factor for TNs in T2DM patients(P<0.05).RCS analysis showed that there was a linear dose-response relationship between TyG and TN risk in T2DM patients(P overll<0.001,P non-linear=0.65).Conclusion TyG is an independent risk factor for TNs in T2DM patients.As the TyG increases,the incidence of TNs in T2DM patients significantly increases.

关 键 词：糖尿病 2型 TyG指数 甲状腺结节 

分 类 号：R587.1[医药卫生—内分泌]