猫面部信息素类似物对减轻猫应激反应的有效性评估  

Evaluation of the Effectiveness of Feline Facial Pheromone Analogues in Reducing Stress Responses in Cats

作　　者：冻杨美 张培杨 潘贵珍 张凯迪 王淑慧 周德刚 DONG Yangmei;ZHANG Peiyang;PAN Guizhen;ZHANG Kaidi;WANG Shuhui;ZHOU Degang(National Research Center for Veterinary Medicine,Luoyang 471032,China;Luoyang Huizhong Animal Medicine Co.,Ltd.,Luoyang 471022,China;Zhengzhou Chongbeide Bio-Technology Co.,Ltd.,Zhengzhou 450015,China)

机构地区：[1]国家兽用药品工程技术研究中心,河南洛阳471032 [2]洛阳惠中兽药有限公司,河南洛阳471022 [3]郑州宠倍得生物科技有限公司,河南郑州450015

出　　处：《中国兽医杂志》2025年第4期120-126,共7页Chinese Journal of Veterinary Medicine

摘　　要：为了探究猫面部信息素类似物对猫应激反应的缓解效果,本试验共筛选了70只试验猫,并随机分为试验药物组(n=37)和安慰剂组(n=33),2个组试验猫分别喷洒给予4~6次试验药物或安慰剂,记录用药前后猫应激行为表现,统计2个组试验猫应激行为发生率和应激行为数量,并按照猫压力评分标准对试验猫进行压力评分。结果显示,用药后,试验药物组猫耳朵贴平的应激行为发生率极显著低于用药前(P<0.01),全身蜷缩、紧张性不动和嘶叫的应激行为发生率显著低于用药前(P<0.05),而安慰剂组用药前后除嘶叫外,其余各应激行为发生率无显著差异(P>0.05);试验药物组和安慰剂组用药前应激行为数量≥3种的猫占比分别为75.7%(28/37)和87.9%(29/33),≥4种的猫占比分别为32.4%(12/37)和45.5%(15/33),试验药物组用药后应激行为数量≥3种和≥4种的猫占比分别为16.2%(6/37)和2.7%(1/37),均极显著低于用药前(P<0.01),但安慰剂组用药前后应激行为数量≥3种和≥4种的猫占比无显著差异(P>0.05);试验药物组猫用药后的压力评分平均值(2.78)极显著低于用药前(4.86)(P<0.01),且极显著低于安慰剂组(4.73)(P<0.01),但安慰剂组用药前后无显著差异(P>0.05)。结果表明,猫面部信息素类似物可明显降低猫的应激行为发生率和应激行为数量,且可缓解猫的应激压力。本试验结果可为新兽药的开发和临床应用提供参考依据。To investigate the efficacy of feline facial pheromone analogues in alleviating stress responses in cats,this study included 70 cats,randomly divided into two groups:the Experimental drug group(n=37)and the Placebo group(n=33).Each group of cats was sprayed with either the experimental drug or placebo 4-6 times.The cats′stress behaviors were recorded before and after medication,and the occurrence rate and number of stress behaviors were statistically analyzed.The stress levels were also scored according to the feline stress scoring system.The results showed that after medication,the Experimental drug group exhibited a significant reduction in stress behaviors such as ear flattening(P<0.01)and significantly lower occurrences of curling,motionless,and vocalizations(P<0.05)compared with before medication.In contrast,the Placebo group showed no significant differences in the occurrence of these stress behaviors except vocalization before and after medication(P>0.05).Before medication,75.7%(28/37)of the cats in the Experimental drug group and 87.9%(29/33)in the Placebo group exhibited three or more stress behaviors,while 32.4%(12/37)and 45.5%(15/33)had four or more behaviors.After medication,only 16.2%(6/37)and 2.7%(1/37)of the Experimental drug group exhibited three or more and four or more behaviors,respectively,which was significantly lower(P<0.01)compared with before medication.The Placebo group showed no significant change in the number of stress behaviors(P>0.05).The average stress score for the Experimental drug group after treatment(2.78)was significantly lower than before treatment(4.86)(P<0.01),and also significantly lower than the Placebo group(4.73)(P<0.01).No significant change was observed in the Placebo group(P>0.05).The results indicate that the feline facial pheromone analogues can significantly reduce the occurrence and number of stress behaviors and alleviate the stress levels of cats.These findings provide a reference for the development and clinical application of new veterinary drugs.

关 键 词：猫 应激 面部信息素类似物 压力评分 临床疗效 

分 类 号：S854.5[农业科学—临床兽医学]