多模态超声成像可视化三阴性乳腺癌微环境:技术突破与挑战  

Visualization of triple negative breast cancer tumor microenvironment with multimodal ultrasound imaging:technological advances and challenges

作　　者：丹庆 朱奕欣 陈芸[1,2] 孙德胜[1,2] DAN Qing;ZHU Yixin;CHEN Yun;SUN Desheng(Department of Ultrasound,Peking University Shenzhen Hospital,Shenzhen 518036,Guangdong,China;Ultrasonic Institute,Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center,Shenzhen 518036,Guangdong,China)

机构地区：[1]北京大学深圳医院超声影像科,广东深圳518036 [2]深圳北京大学-香港科技大学医学中心超声研究所,广东深圳518036

出　　处：《西部医学》2025年第4期469-476,共8页Medical Journal of West China

基　　金：2023国家重点研发计划资助项目(2023YFC3402605);2024国家自然科学基金面上项目(82471988);2024深圳市自然科学基金面上项目(JCYJ20240813115925033,JCYJ20240806134133002);深圳市“医疗卫生三名工程”项目资助(SZSM202111011)。

摘　　要：三阴性乳腺癌(TNBC)的预后与肿瘤微环境(TME)密切相关,TME通过血管异常、基质硬化及免疫抑制等机制驱动TNBC侵袭转移,是导致其治疗失败的重要原因。因此,深入了解TME对提高TNBC患者的治疗效能与生存预后具有重要意义。随着科学技术的发展,多模态超声在无创、动态可视化TME中提供了高效的手段。本文对TNBC的TME特征、多模态超声成像技术以及人工智能在TME可视化中的应用进展进行述评,旨在为TNBC的精准诊疗提供指导与参考。The prognosis of triple negative breast cancer(TNBC)is closely associated with the tumor microenvironment(TME).TME drives TNBC invasion and metastasis through mechanisms such as vascular abnormalities,stromal stiffening,and immune suppression,which are critical factors contributing to treatment failure in TNBC.Therefore,a deeper understanding of TME is of great significance for improving therapeutic efficacy and survival outcomes in TNBC.With advancements in science and technology,multimodal ultrasound has emerged as efficient tools for non-invasive and dynamic visualization of TME.This article reviews the characteristics of TNBC TME and the progress in the application of multimodal ultrasound imaging and artificial intelligence for TME visualization,aiming to provide guidance for the precise diagnosis,treatment,and personalized management of TNBC.

关 键 词：三阴性乳腺癌 肿瘤微环境 多模态超声 人工智能 

分 类 号：R445.1[医药卫生—影像医学与核医学] R737.9[医药卫生—诊断学]