激光剥蚀电感耦合等离子体质谱法与薄层色谱法联用技术研究进展  

Recent Advance in Studies on Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry(LA-ICP-MS) Combined with Thin Layer Chromatography(TLC)

作　　者：柯于球 郑腾飞[1,2] 张兆雪[1,2] 李海涛 易小庆 周健宗 KE Yuqiu;ZHENG Tengfei;ZHANG Zhaoxue;LI Haitao;YI Xiaoqing;ZHOU Jianzong(Key Laboratory of Testing and Tracing of Rare Earth Products,State Administration for Market Regulation,School of Chemistry and Chemical Engineering,Jiangxi University of Science and Technology,Ganzhou,Jiangxi 341000,China;School of Chemistry and Chemical Engineering,School of Chemistry and Chemical Engineering,Jiangxi University of Science and Technology,Ganzhou,Jiangxi 341000,China;Key Laboratory of Testing and Tracing of Rare Earth Products,State Administration for Market Regulation,School of Resources and Environmental Engineering,Jiangxi University of Science and Technology,Ganzhou,Jiangxi 341000,China;College of Pharmacy,Gannan Medical University,Ganzhou,Jiangxi 341000,China)

机构地区：[1]江西理工大学化学化工学院国家市场监督管理总局重点实验室(稀土产品检测与溯源),江西赣州341000 [2]江西理工大学化学化工学院功能晶态材料化学江西省重点实验室,江西赣州341000 [3]江西理工大学资源与环境工程学院国家市场监督管理总局重点实验室(稀土产品检测与溯源),江西赣州341000 [4]赣南医科大学药学院,江西赣州341000

出　　处：《中国无机分析化学》2025年第5期628-643,共16页Chinese Journal of Inorganic Analytical Chemistry

基　　金：国家自然科学基金资助项目(42363002,22364004);江西省自然科学基金资助项目(20232BAB203065,20242BAB23028)。

摘　　要：激光剥蚀电感耦合等离子体质谱法(LA-ICP-MS)可实现固体样品原位微区分析,但在进行复杂样品分析时,仍然需要借助色谱分离技术。薄层色谱法(TLC)在实现多组分色谱分离的同时,还可以将液态样品转化为固态,可与LA-ICP-MS进行联用,从而实现复杂样品直接分析。对TLC-LA-ICP-MS在形态分析、纳米材料分析和石油分析领域的应用现状进行了综述,对薄层色谱板的固定相、流动相以及展开路径等色谱分离条件、激光剥蚀能量、线扫描速率、内标校正、质谱干扰等LA-ICP-MS测试条件和分析方法性能进行了分析,对TLC-LA-ICP-MS在形态分析以及金属原子簇领域的应用进行了展望。Laser ablation-inductively coupled plasma-mass spectrometry(LA-ICP-MS) enables in-situ microanalysis of solid samples.However,for the analysis of complex samples,chromatographic separation treatments are still needed.Thin layer chromatography(TLC) not only enables chromatographic separation but also converts liquid samples into solid form,allowing for coupling with LA-ICP-MS.The current applications of TLCLA-ICP-MS in the fields of speciation analysis,nanomaterial analysis,and petroleum analysis were reviewed.The chromatographic separation conditions,including stationary phase,mobile phase,and development path of TLC plates,as well as the LA-ICP-MS testing conditions and method performance,such as laser energy,scan rate,internal standard,and mass spectral interferences,were summarized.Additionally,the prospects of TLC-LA-ICP-MS in speciation analysis and metallic nanocluster analysis were discussed.

关 键 词：激光剥蚀电感耦合等离子体质谱法 薄层色谱法 形态分析 纳米材料分析 石油分析 

分 类 号：O657.63[理学—分析化学]