血清sST2、Copeptin对急性有机磷中毒患者继发心肌损伤的预测价值分析  

Predictive value of serum sST 2 and copeptin expression for myocardial injury caused by acute organophosphate poisoning

作　　者：郭鹏 周晓鲁[1] GUO Peng;ZHOU Xiaolu(Department of Emergency,Anyang Fifth People's Hospital,Anyang,Henan 455000,China)

机构地区：[1]河南省安阳市第五人民医院急诊科,455000

出　　处：《淮海医药》2025年第2期144-147,共4页Journal of Huaihai Medicine

基　　金：河南省医学科技攻关项目(LHGJ202010208)。

摘　　要：目的:分析血清可溶性生长刺激表达基因2蛋白(sST2)、和肽素(CPP)水平对急性有机磷中毒(AOPP)患者继发心肌损伤的预测价值。方法:选取某院2022年1月—2024年5月收治的115例AOPP患者为研究对象,根据是否合并心肌损伤分为合并组(n=35)和未合并组(n=80)。单因素及多因素Logistic回归方程分析AOPP患者继发心肌损伤的危险因素,Pearson系数分析血清sST2、CPP水平与心肌损伤标志物[肌红蛋白(MYO)、心肌肌钙蛋白(cTnT)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)]的相关性,绘制受试者工作特征(ROC)曲线评估血清sST2、CPP水平对AOPP患者继发心肌损伤的预测价值。结果:单因素分析显示,合并组年龄、中毒至送医时间、重度中毒占比、服药量、入院时急性生理与慢性健康评分(APACHEⅡ)、合并呼吸衰竭占比及MYO、cTnT、CK-MB、LDH、sST2、CPP水平均高于未合并组,差异有统计学意义(P<0.05);多因素Logistic回归分析显示,年龄、中毒至送医时间、重度中毒、合并呼吸衰竭及MYO、cTnT、CK-MB、LDH、sST2、CPP水平为AOPP患者继发心肌损伤的危险因素(P<0.05)。Pearson相关性分析显示,血清sST2、CPP水平与MTO、cTnT、CK-MB、LDH水平呈正相关(P<0.05)。ROC曲线显示,血清sST2、CPP水平预测AOPP患者继发心肌损伤的AUC分别为0.861、0.859。结论:血清sST2、CPP水平随着AOPP患者的心肌损伤程度加剧而不断升高,动态监测二者水平变化能实现对患者继发心肌损伤风险的早期预测。Objective:To analyze the predictive value of serum soluble growth stimulating expressed gene 2 protein(sST2)and peptide peptides(CPP)expression levels for myocardial injury in patients with acute organophosphate poisoning(AOPP).Methods:115 AOPP patients admitted to our hospital from January 2022 to May 2024 were selected in this retrospective study.The patients were classified into a merged group(35 cases)and a non merged group(80 cases)based on whether they had myocardial injury.General and clinical data of the two groups of patients were collected and compared.The risk factors of the AOPP patients with secondary myocardial injury were summarized through single factor analysis and multi factor regression equation analysis.Pearson correlation coefficient was used to test the correlation between serum sST2,CPP and myocardial injury markers[myoglobin(MYO),cardiac troponin T(cTnT),creatine kinase isoenzyme(CK-MB),lactate dehydrogenase(LDH)].The predictive value of serum sST2 and CPP for the risk of myocardial injury in AOPP patients was assessed through drawing Receiver Operating Characteristic Curve(ROC).Results:The results of univariate analysis showed that the age,time from poisoning to hospitalization,proportion of severe poisoning,medication dosage,acute physiology and chronic health score(APACHE II)at admission,proportion of respiratory failure,and levels of MYO,cTnT,CK-MB,LDH,sST2,and CPP in the merged group were all higher than those in the non merged group(P<0.05).Logistic multi factor regression equation analysis showed that the age,time from poisoning to hospitalization,severe poisoning,combined respiratory failure,and levels of MYO,cTnT,CK-MB,LDH,sST2,and CPP were risk factors for AOPP patients with secondary myocardial injury.Pearson correlation coefficient test showed that serum sST2 and CPP was positively correlated with MTO,cTnT,CK-MB,and LDH(P<0.05).The ROC curve showed that the AUC of serum sST2 and CPP for predicting secondary myocardial injury in AOPP patients were 0.861 and 0.859,respectively.Co

关 键 词：有机磷中毒 心肌损伤 可溶性生长刺激表达基因2蛋白 和肽素 预测价值 

分 类 号：R595.51[医药卫生—内科学]