麦粒灸四花穴联合揿针治疗肝气郁结型抑郁症的临床研究  

Clinical Study on Wheat-grain size cone moxibustion at Sihua Acupoints Combined with Thumbtack Needle for the Treatment of Depression with Liver Qi Stagnation Pattern

作　　者：陈哲子[1] 伍秋月 刘玉莲[1] CHEN Zhezi;WU Qiuyue;LIU Yulian(Foshan Hospital of Traditional Chinese Medicine,Foshan 528000,China)

机构地区：[1]佛山市中医院,广东佛山528000

出　　处：《中医药学报》2025年第4期43-48,共6页Acta Chinese Medicine and Pharmacology

基　　金：广东省卫生健康委科研基金(GDYYB21058)。

摘　　要：目的:研究麦粒灸四花穴联合揿针治疗肝气郁结型抑郁症的临床疗效。方法:选择2022年6月—2023年6月于佛山市中医院治疗的83例抑郁症患者,采用随机数字表法分为两组,对照组(脱落2例,最终纳入40例)给予西医治疗,研究组(脱落1例,最终纳入40例)在对照组治疗基础上给予麦粒灸四花穴联合揿针治疗,治疗4周后比较两组临床疗效,治疗前后评价患者贝克抑郁量表(BDI-Ⅱ)、9项患者健康问卷抑郁量表(PHQ-9)、简易应对方式量表(SCSQ),检测患者微觉醒指数、睡眠总时间、睡眠效率,检测巨噬细胞移动抑制因子(MIF)、γ-氨基丁酸(GABA)、5-羟色胺(5-HT)、肿瘤坏死因子-α(TNF-α)、CC趋化因子配体2(CCL2)、高香草酸(HVA)、3G甲基G4羟苯乙二醇(MHPG)水平。结果:研究组总有效率为97.50%(39/40),对照组总有效率为80.00%(32/40),研究组患者总有效率高于对照组(P<0.05);研究组BDI-Ⅱ、PHQ-9评分较对照组低(P<0.01),研究组SCSQ评分较对照组高(P<0.01);研究组微觉醒指数较对照组少(P<0.01),研究组睡眠效率较对照组高(P<0.01),研究组睡眠总时间较对照组长(P<0.01);麦粒灸联合揿针组MIF、TNF-α、CCL2含量较对照组明显降低(P<0.01);研究组GABA、5-HT、HVA、MHPG水平较对照组高(P<0.01)。结论:麦粒灸四花穴联合揿针治疗肝气郁结型抑郁症患者,可减少炎症损伤,改善神经递质水平,缓解抑郁症状,改善睡眠质量及问题应对方式,提升临床疗效。Objective:To investigate the clinical efficacy of Wheat-Grain Size Cone Moxibustion at Sihua acupoints combined with thumbtack needling in treating depression with liver qi stagnation pattern.Methods:A total of 83 patients with depression treated at Foshan Hospital of Traditional Chinese Medicine from June 2022 to June 2023 were selected and randomly divided into two groups using a random number table.The control group(42 cases,2 dropped out,40 finally included)received conventional Western medicine treatment,while the study group(41 cases,1 dropped out,40 finally included)received the same plus wheat-grain size cone moxibustion at Sihua acupoints combined with thumbtack needling based on the control group's treatment.Clinical efficacy was compared after 4 weeks of treatment.Before and after treatment,patients were assessed using the Beck Depression Inventory-Ⅱ(BDI-Ⅱ),9-item Patient Health Questionnaire Depression Scale(PHQ-9),and Simplified Coping Style Questionnaire(SCSQ).Microarousal index,total sleep time,and sleep efficiency were measured.Levels of macrophage migration inhibitory factor(MIF),γ-aminobutyric acid(GABA),5-hydroxytryptamine(5-HT),tumor necrosis factor-α(TNF-α),CC chemokine ligand 2(CCL2),homovanillic acid(HVA),and 3-methoxy-4-hydroxyphenylglycol(MHPG)were detected.Results:The total effective rate was 97.50%(39/40)in the study group and 80.00%(32/40)in the control group.The study group showed a higher total effective rate than the control group(P<0.05).BDI-Ⅱ and PHQ-9 scores in the study group were lower than those in the control group(P<0.01),while the SCSQ score was higher(P<0.01).The study group had fewer microarousals(P<0.01),higher sleep efficiency(P<0.01),and longer total sleep time(P<0.01)compared to the control group.The combined moxibustion and thumbtack needling group showed significantly lower levels of MIF,TNF-α,and CCL2 than the control group(P<0.01).Levels of GABA,5-HT,HVA,and MHPG in the study group were higher than those in the control group(P<0.01).Conclusion:Wheat-grai

关 键 词：麦粒灸四花穴 揿针 肝气郁结型抑郁症 炎症损伤 神经递质 睡眠质量 

分 类 号：R246.1[医药卫生—针灸推拿学]