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作 者:朱欢欢 颜蕾 冯泽宇 ZHU Huanhuan;YAN Lei;FENG Zeyu(Department of Anorectal Surgery,Wuxi Hospital of Traditional Chinese Medicine,Wuxi 214000,China)
出 处:《中医药学报》2025年第4期77-81,共5页Acta Chinese Medicine and Pharmacology
基 金:江苏省卫生健康委科研项目(M2022021);无锡市“双百”卫生健康中青年拔尖人才项目(BJ2023067)。
摘 要:目的:探究双歧杆菌三联活菌胶囊与健脾补肾方联合治疗功能性便秘脾肾阳虚证的临床效果。方法:采用随机数字表法将无锡市中医医院2021年1月—2023年12月收治的功能性便秘患者82例分成常规组与联合组,每组41例。常规组口服双歧杆菌三联活菌胶囊,在此基础上联合组加用健脾补肾方。观察两组患者的中医证候积分、血清学指标、肛门直肠动力学指标、便秘患者症状自评量表(PAC-SYM)评分及肠功能指数(BFI)、临床疗效、不良反应发生情况。结果:治疗后,联合组中医证候积分、PAC-SYM与BFI评分、生长抑素(SS)、胃肠激素活动性肠肽(VIP)、荧光法测定一氧化氮(NO)水平及肛门直肠最大耐受容量均低于常规组(P<0.01);联合组胃动素(MTL)、胃泌素(GAS)、P物质(SP)水平、肛管静息压与收缩压与治疗总有效率均高于常规组(P<0.05,P<0.01);两组不良反应总发生率差异无统计学意义(P>0.05)。结论:健脾补肾方与双歧杆菌三联活菌胶囊合用可降低患者中医证候积分,改善便秘等临床症状,提高胃肠道功能与临床疗效,且安全性较高。Objective:To explore the clinical efficacy of Bifidobacterium triple viable capsules combined with Jianpi Bushen Formula in treating functional constipation with spleen and kidney yang deficiency syndrome.Methods:A randomized digital table method was used to divide 82 patients with functional constipation,admitted to Wuxi Hospital of Traditional Chinese Medicine from January 2021 to December 2023,into a conventional group and a combination group,with 41 cases in each group.The conventional group received oral Bifidobacterium triple viable capsules,while the combination group was additionally treated with Jianpi Bushen Formula.The Traditional Chinese Medicine(TCM)syndrome scores,serological indices,anorectal dynamics indices,Patient Assessment of Constipation Symptoms(PAC-SYM)scores,Bowel Function Index(BFI),clinical efficacy,and adverse events were observed in both groups.Results:After treatment,the combination group showed significantly lower TCM syndrome scores,PAC-SYM and BFI scores,somatostatin(SS),vasoactive intestinal peptide(VIP),nitric oxide(NO)levels,and anorectal maximum tolerable volume compared to the conventional group(P<0.01).The combination group had significantly higher motilin(MTL),gastrin(GAS),substance P(SP)levels,anal resting pressure,anal contraction pressure,and overall treatment efficacy compared to the conventional group(P<0.05,P<0.01).No significant difference was observed in the total incidence of adverse events between the two groups(P>0.05).Conclusion:The combination of Jianpi Bushen Formula and Bifidobacterium triple viable capsules can reduce TCM syndrome scores,alleviate constipation symptoms,improve gastrointestinal function,and enhance clinical efficacy,with high safety.
关 键 词:健脾补肾方 双歧杆菌三联活菌胶囊 功能性便秘 脾肾阳虚证
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