微生物合成褪黑素研究进展  

Progress in the Synthesis of Melatonin by Microorganisms

作　　者：朱小东 赵长乐 乔建军[1,2,3,4] 李艳妮 ZHU Xiaodong;ZHAO Changle;QIAO Jianjun;LI Yanni(School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China;Key Laboratory of Systems Bioengineering of Ministry of Education,Tianjin University,Tianjin 300072,China;Zhejiang Institute of Tianjin University(Shaoxing),Shaoxing 312300,China;Synthetic Biology Research Platform,Tianjin Collaborative Innovation Center of Chemical Science and Engineering,Tianjin 300072,China)

机构地区：[1]天津大学化工学院,天津300072 [2]天津大学系统生物工程教育部重点实验室,天津300072 [3]天津大学浙江研究院(绍兴),绍兴312300 [4]天津化学化工协同创新中心合成生物学平台,天津300072

出　　处：《中国生物工程杂志》2025年第2期137-146,共10页China Biotechnology

基　　金：国家重点研发计划(2020YFA0907900)资助项目。

摘　　要：褪黑素作为哺乳动物中重要的激素,不仅可以调节昼夜节律周期和促进睡眠,同时在抗氧化、抗炎等方面也具有显著作用。随着对褪黑素需求的增加,传统生产方式已不能满足人们的需求,微生物异源合成褪黑素因其低成本、可持续性等优点而受到广泛关注。褪黑素在不同生物中的合成途径存在差异,通过代谢工程优化、酶的挖掘与表征等研究,已经在微生物合成褪黑素方面取得了丰硕成果。对近年来微生物合成褪黑素的策略和合成途径进行了综述,同时也指出了存在的瓶颈,为后续提高产量及实现工业化生产提供了有效参考。Melatonin,as an important hormone in mammals,not only regulates circadian rhythms and promotes sleep,but also plays a significant role in antioxidation and anti-inflammation.With the increasing demand for melatonin,traditional production methods are no longer sufficient to meet people’s needs.Microbial heterologous synthesis of melatonin has received widespread attention due to its low cost and sustainability.Although the synthetic pathways of melatonin vary in different organisms,fruitful results have been achieved in the microbial synthesis of melatonin through metabolic engineering optimization,as well as enzyme research and characterization.A review of the strategies and synthetic pathways for microbial synthesis of melatonin in recent years has been provided,highlighting the existing bottlenecks and providing effective references for increasing subsequent yields and achieving industrial-scale production.

关 键 词：褪黑素 生物合成 细胞工厂 代谢工程 

分 类 号：Q819[生物学—生物工程]