外泌体参与骨性关节炎发病过程的作用机制及针刺调节作用  

The Role of Exosomes in the Pathogenesis of Osteoarthritis and the Regulatory Effects of Acupuncture

作　　者：丁静 郑洁[1] DING Jing;ZHENG Jie(Shaanxi University of Chinese Medicine,Xianyang 712046,China)

机构地区：[1]陕西中医药大学,陕西咸阳712046

出　　处：《针灸临床杂志》2025年第4期6-12,共7页Journal of Clinical Acupuncture and Moxibustion

基　　金：国家自然科学基金,编号:82374265;陕西省科技厅项目,编号:2022SF-184。

摘　　要：中医针刺疗法已广泛应用于骨性关节炎疾病治疗中,研究发现针刺主要通过改善骨性关节炎(OA)局部微环境、调节炎症反应、免疫系统和神经系统等方面,缓解OA的病理进程。目前针刺的治疗作用机制还待进一步研究证实,其起效机制尚未完全明确。外泌体作为一种细胞外释放的小囊泡,在细胞信息传递和细胞功能调控中起着关键作用,针刺可以调节外泌体的释放,前期研究表明外泌体及其释放物质可将其针刺信号级联放大。本研究探讨外泌体在OA发病过程的作用及针刺调节作用,为针刺治疗OA的深入机制提供依据。Acupuncture therapy has been widely applied in the treatment of osteoarthritis(OA).Studies have shown that acupuncture primarily alleviates OA pathology by improving the local microenvironment,regulating inflammatory response,and modulating the immune and nervous systems.However,the precise therapeutic mechanisms of acupuncture remain unclear and require further investigation.Exosomes,as small extracellular vesicles released by cells,play a crucial role in cellular communication and functional regulation.Acupuncture has been found to influence exosomes release,and preliminary studies suggest that exosomes and the released substances may amplify acupuncture signals in a cascade-like manner.This study explores the role of exosomes in the pathogenesis of OA and the regulatory effect of acupuncture,providing a theoretical basis for exploring the deeper mechanisms of acupuncture in the treatment of OA.

关 键 词：骨性关节炎 外泌体 针刺 

分 类 号：R246.2[医药卫生—针灸推拿学]