Animal models of human herpesvirus infection  

作　　者：Ziqing Jia Dong Zhang Lin Zhu Jing Xue 

机构地区：[1]NHC Key Laboratory of Human Disease Comparative Medicine,Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China [2]State Key Laboratory of Respiratory Health and Multimorbidity,Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China [3]Key Laboratory of Pathogen Infection Prevention and Control(Peking Union Medical College),Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases,Institute of Laboratory Animal Science,Ministry of Education,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China

出　　处：《Animal Models and Experimental Medicine》2025年第4期615-628,共14页动物模型与实验医学(英文)

基　　金：National Natural Science Foundation of China,Grant/Award Number:82222041 and 82241068;CAMS Innovation Fund for Medical Sciences,Grant/Award Number:2021-I2M-1-037 and 2023-I2M-2-001;National Key Research and Development Project of China,Grant/Award Number:2023YFC2309000;Beijing Natural Science Foundation,Grant/Award Number:Z220018。

摘　　要：Human herpesvirus,a specific group within the herpesvirus family,is responsible for a variety of human diseases.These viruses can infect humans and other vertebrates,primarily targeting the skin,mucous membranes,and neural tissues,thereby signifi-cantly impacting the health of both humans and animals.Animal models are crucial for studying virus pathogenesis,vaccine development,and drug testing.Despite several vaccine candidates being in preclinical and clinical stages,no vaccines are current available to prevent lifelong infections caused by these human herpesviruses,except for varicella-zoster virus(VZV)vaccine.However,the strict host tropism of herpes-viruses and other limitations mean that no single animal model can fully replicate all key features of human herpesvirus-associated diseases.This makes it challeng-ing to evaluate vaccines and antivirals against human herpesvirus comprehensively.Herein,we summarize the current animal models used to study the human herpesvi-ruses includingα-herpesviruses(herpes simplex virus type 1(HSV-1),HSV-2,VZV),β-herpesviruses(human cytomegalovirus(HCMV),γ-herpesviruses(Epstein-Barr virus(EBV))and Kaposi's sarcoma herpesvirus(KSHV)).By providing concise information and detailed analysis of the potential,limitations and applications of various models,such as non-human primates,mice,rabbits,guinea pigs,and tree shrews,this sum-mary aims to help researchers efficiently select the most appropriate animal model,offering practical guidance for studying human herpesvirus.

关 键 词：animal models EBV HSV human herpesvirus KSHV VZV 

分 类 号：R373[医药卫生—病原生物学]