Fevogrit,a polyherbal medicine,mitigates endotoxin(lipopolysaccharide)-induced fever in Wistar rats by regulating pro-inflammatory cytokine levels  

作　　者：Acharya Balkrishna Sonam Sharma Vivek Gohel Rani Singh Meenu Tomer Rishabh Dev Sandeep Sinha Anurag Varshney 

机构地区：[1]Drug Discovery and Development Division,Patanjali Research Foundation,Haridwar,India [2]Department of Allied and Applied Sciences,University of Patanjali,Haridwar,India [3]Patanjali UK Trust,Glasgow,UK [4]Patanjali Yogpeeth Nepal,Mandikhatar,Kathmandu,Nepal [5]Special Centre for Systems Medicine,Jawaharlal Nehru University,New Delhi,India

出　　处：《Animal Models and Experimental Medicine》2025年第4期728-738,共11页动物模型与实验医学(英文)

基　　金：This study was supported by internal funds from Patanjali Research Foundation Trust,Haridwar,India。

摘　　要：Background:Fever is characterized by an upregulation of the thermoregulatory set-point after the body encounters any pathological challenge.It is accompanied by uncomfortable sickness behaviors and may be harmful in patients with other comor-bidities.We have explored the impact of an Ayurvedic medicine,Fevogrit,in an endo-toxin(lipopolysaccharide)-induced fever model in Wistar rats.Methods:Active phytoconstituents of Fevogrit were identified and quantified using ultra-high-performance liquid chromatography(UHPLC)platform.For the in-vivo study,fever was induced in male Wistar rats by the intraperitoneal administration of lipopolysaccharide(LPS),obtained from Escherichia coli.The animals were allocated to normal control,disease control,Paracetamol treated and Fevogrit treated groups.The rectal temperature of animals was recorded at different time points using a digital thermometer.At the 6-h time point,levels of TNF-α,IL-1βand IL-6 cytokines were analyzed in serum.Additionally,the mRNA expression of these cytokines was deter-mined in hypothalamus,24 h post-LPS administration.Results:UHPLC analysis of Fevogrit revealed the presence of picroside I,picroside II,vanillic acid,cinnamic acid,magnoflorine and cordifolioside A,as bioactive constitu-ents with known anti-inflammatory properties.Fevogrit treatment efficiently reduces the LPS-induced rise in the rectal temperature of animals.The levels and gene ex-pression of TNF-α,IL-1βand IL-6 in serum and hypothalamus,respectively,was also significantly reduced by Fevogrit treatment.Conclusion:The findings of the study demonstrated that Fevogrit can suppress LPS-induced fever by inhibiting peripheral or central inflammatory signaling pathways and could well be a viable treatment for infection-induced increase in body temperatures.

关 键 词：AYURVEDA FEVER Fevogrit LIPOPOLYSACCHARIDE pro-inflammatory cytokines 

分 类 号：R285.5[医药卫生—中药学]