Use of laryngeal muscle evoked potential recording for experimental vagus nerve stimulation  

作　　者：Helen Bachmann Robrecht Raedt Guy Laureys Kristl Vonck 

机构地区：[1]Brain,Department of Neurology,Ghent University Hospital,Ghent University,Gent,Belgium

出　　处：《Animal Models and Experimental Medicine》2025年第4期750-757,共8页动物模型与实验医学(英文)

基　　金：The Research Foundation Flanders(FWO),Grant/Award Number:1S25620N;The Charcot Research Fund。

摘　　要：The laryngeal muscle evoked potential(LMEP)is a neurophysiological outcome parameter that guarantees integrity of the nerve-electrode interface during experiments with vagus nerve stimulation(VNS).This paper discusses a large series of minimally invasive LMEP recordings in 46 female Lewis rats,implanted with a custom-made VNS electrode around the left cervical vagus nerve.After a 3-week recovery,LMEPs were recorded twice in each animal,with swapping the anode and cathode positions of the VNS electrode(polarity inversion).A VNS-induced LMEP was identified as the initial negative peak wave post-stimulation artifact,consistently recorded in all sweeps at a given stimulation output current.Latency was defined as the time from stimulation onset to this negative peak,and stimulation threshold as the lowest current showing a clear and reproducible LMEP.An LMEP response was shown by 37/46 animals(80.4%),with stimulation intensity threshold of 0.37±0.27 mA and latency of 2.39±0.45 ms.Administering the cathodic pulse phase first at the caudal electrode contact resulted in the shortest LMEP latencies(MWU:p=0.049.2.36±0.43 ms vs.2.41±0.47 ms).Minimally invasive LMEP recording provides a feasible and reliable means for checking electrode functioning and correct implantation.

关 键 词：laryngeal muscles motor evoked potential vagus nerve vagus nerve stimulation 

分 类 号：R318[医药卫生—生物医学工程]