基于扩散谱成像探究T2DM胼胝体微结构改变与肠道菌群之间的关系  

Exploring the Relationship between Microstructural Changes in the Corpus Callosum and Gut Microbiota in T2DM Using Diffusion Spectrum Imaging

作　　者：汪旭洋 许珊 杨东 伍建林[1] WANG Xu-yang;XU Shan;YANG Dong;WU Jian-lin(Department of Radiology,Zhongshan Hospital,Dalian University,Dalian 116000,Liaoning Province,China)

机构地区：[1]大连大学附属中山医院放射科,辽宁大连116000

出　　处：《中国CT和MRI杂志》2025年第4期14-16,20,共4页Chinese Journal of CT and MRI

基　　金：国家自然科学基金(82071911);大连市科技创新基金(2021JJ12SN38)。

摘　　要：目的基于扩散谱成像探究T2DM患者胼胝体体部白质微结构改变与肠道菌群之间的关系。方法招募34名T2DM患者及年龄、性别相匹配的20名健康志愿者,采集所有受试者的DSI图像,通过DSIstudio软件进行Q空间微分同构重建并对胼胝体体部进行确定性纤维追踪获得相应扩散参数,分析T2DM与HC组受试者胼胝体体部扩散磁共振参数的差异。同时,通过高通量测序获得所有被试优势菌群的丰度数据,并比较种水平上优势菌群丰度的组间差异。将性别、年龄作为协变量,通过spearman偏相关分析计算T2DM患者具有差异的磁共振指标与差异菌门之间的相关性。结果T2DM组胼胝体体部的定量各向异性参数低于HC组(P=0.005)。相对于HC组,T2DM组在种水平上长双歧杆菌丰度较高(P=0.014)而卵形拟杆菌丰度较低(P=0.001),其中T2DM组长双歧杆菌的丰度与定量各向异性呈负相关(P<0.05)。结论T2DM患者胼胝体体部可能存在白质微结构损伤,并且这种白质结构的改变与肠道菌群的改变之间存在一定关联。Objective To investigate the relationship between the white matter microstructure of corpus callosum and gut microbiota in patients with type 2 diabetes mellitus(T2DM)based on diffusion spectrum imaging.Methods Thirty-four T2DM patients and 20 age-and sex-matched healthy volunteers were recruited.DSI images of all subjects were collected.Q-space diffeomorphism reconstruction was performed by DSI-Studio software,and the corresponding diffusion parameters of the corpus callosum were obtained by deterministic fiber tracking.The differences of diffusion magnetic resonance parameters of corpus callosum between T2DM and HC groups were analyzed.At the same time,the abundance data of dominant flora of all subjects were obtained by high-throughput sequencing,and the differences in the abundance of dominant flora at the species level between groups were compared.Taking gender and age as covariates,spearman partial correlation analysis was used to calculate the correlation between the MRI parameters with differences and the different phyla in T2DM patients.Results The T2DM group had significantly lower quantitative anisotropy parameters of the corpus callosum than the HC group(P=0.005).Compared with the HC group,the T2DM group had a significantly higher abundance of longum(P=0.014)and a significantly lower abundance of ovatus(P=0.001)at the species level.The abundance of longum in the T2DM group was negatively correlated with the quantitative anisotropy(P<0.05).Conclusion There may be white matter microstructural damage in the corpus callosum of T2DM patients,and there is a certain correlation between the changes of white matter structure and the changes of gut microbiota.

关 键 词：2型糖尿病 扩散谱成像 肠道菌群 胼胝体 

分 类 号：R445.2[医药卫生—影像医学与核医学] R587.2[医药卫生—诊断学]