基于MRI评价帕金森患者脑灰质体积变化及其认知功能的关系  

Evaluation of the Relationship between Gray Matter Volume Changes and Cognitive Function in Patients with Parkinson's Disease Based on MRI

作　　者：智文虹 姚惠敏 李再利[1] 黄亚勇[2] 刘志广[1] ZHI Wen-hong;YAO Hui-min;LI Zai-li;Huang Ya-yong;LIU Zhi-guang(Department of Neurology,Xuzhou Central Hospital,Xuzhou 221000,Jiangsu Province,China;Department of Medical Imaging,Xuzhou Central Hospital,Xuzhou 221000,Jiangsu Province,China)

机构地区：[1]徐州市中心医院神经内科,江苏徐州221000 [2]徐州市中心医院医学影像科,江苏徐州221000

出　　处：《中国CT和MRI杂志》2025年第4期43-45,共3页Chinese Journal of CT and MRI

基　　金：徐州市科技项目(KC21234)。

摘　　要：目的基于磁共振成像(MRI)评价帕金森病(PD)患者脑灰质体积(GMV)变化及其认知功能的关系。方法回顾性选取2021年1月至2023年12月我院收治的138例PD患者,根据中文版简易智能状态检查量表(MMSE)评分结果,77例患者纳入分为PD认知障碍(PD-CI)组,61例患者纳入PD认知正常(PDNC)组,另外选取同时期至我院行体检的50例健康者作为对照组。三组患者均行头部MRI检查,比较三组基线资料、全脑灰质密度和GMV,分析脑内GMV变化与认知功能的关系。结果三组MMSE评分比较,有统计学差异(P<0.05)。三组脑内灰质密度和GMV在左侧丘脑、左侧颞中回和双侧海马旁回存在明显差异(P<0.05)。Pearson分析结果显示,左侧丘脑、左侧颞中回和双侧海马旁回GMV与认知功能呈明显正相关(P<0.05)。结论与健康人群相比,PD患者存在多个脑区灰质密度与体积变化,左侧丘脑、左侧颞中回和双侧海马旁回GMV减小与认知功能受损呈明显相关性。Objective To evaluate the relationship between gray matter volume changes and cognitive function in patients with Parkinson's disease(PD)based on magnetic resonance imaging(MRI).Methods A total of 138 patients with PD admitted to the hospital from January 2021 to December 2023 were reviewed.According to the Chinese version of the Mini-Mental State Examination(MMSE)score,77 patients were included in the PD-cognitive impairment(PD-CI)group and 61 patients were included in PD-normal cognition(PD-NC)group.Meanwhile,50 healthy individuals were selected as the control group.All subjects received head MRI examination.Baseline data,gray matter density of the whole brain and gray matter volume(GMV)of the three groups were compared.The relationship between changes in GMV and cognitive function was analyzed.Results The three groups had significantly different MMSE scores(P<0.05).Moreover,there were significant differences among the three groups in terms of gray matter density and GMV in the left thalamus,left middle temporal gyrus and bilateral parahippocampal gyrus(P<0.05).Pearson analysis results showed that GMV in the left thalamus,left middle temporal gyrus and bilateral parahippocampal gyrus was significantly positively correlated with cognitive function(P<0.05).Conclusion Compared with healthy individuals,patients with PD exhibit changes in gray matter density and volume in multiple brain regions.Decreased gray matter volume in the left thalamus,left middle temporal gyrus and bilateral parahippocampal gyrus is significantly correlated with cognitive impairment.

关 键 词：磁共振成像 体素形态学测量 帕金森病 脑灰质体积 认知功能 

分 类 号：R445.2[医药卫生—影像医学与核医学]