肺磨玻璃结节患者病理分型与高分辨率CT影像特征相关性研究  

A Study on the Correlation between Pathological Classification and Highresolution CT Imaging Features in Patients with Pulmonary Ground Glass Nodules

作　　者：叶远花 程茂军 刘振[1] YE Yuan-hua;CHENG Mao-jun;LIU Zhen(CT and MR Room,The First People's Hospital of Chuzhou(The Affiliated Chuzhou Hospital of Anhui Medical University),Chuzhou 239000,Anhui Province,China)

机构地区：[1]安徽医科大学附属滁州医院(滁州市第一人民医院)CT MR室,安徽滁州239000

出　　处：《中国CT和MRI杂志》2025年第4期71-74,共4页Chinese Journal of CT and MRI

摘　　要：目的探究肺磨玻璃结节患者病理分型与高分辨率CT影像特征相关性。方法选取2020年7月至2023年12月本院收治的82例肺磨玻璃结节患者临床资料实施回顾性研究,按病理结果分为浸润前病变26例、浸润性病变56例(微浸润腺癌22例、浸润性腺癌34例),比较各组高分辨率CT影像特征的差异,分析高分辨率CT影像特征诊断肺磨玻璃结节发生浸润前病变、浸润性腺癌的价值。结果两组年龄、性别、密度、空泡征、空气支气管征差异无统计学意义(P>0.05),但浸润性病变组大小、毛刺征、分叶征、血管集束征、胸膜牵拉征均高于浸润前病变组(P<0.05)。二元Logistic回归分析显示,大小、毛刺征、分叶征、血管集束征、胸膜牵拉征均是肺磨玻璃结节发生浸润性病变的危险因素(P<0.05)。ROC曲线分析显示,毛刺征、分叶征、血管集束征、胸膜牵拉征、大小对肺磨玻璃结节发生浸润性病变均具有一定准确性的诊断价值(AUC=0.783、0.749、0.792、0.686、0.809)。两组密度、空泡征、血管集束征、空气支气管征差异无统计学意义(P>0.05),但浸润性腺癌组大小、毛刺征、分叶征、胸膜牵拉征均高于微浸润腺癌(P<0.05)。二元Logistic回归分析显示,大小、胸膜牵拉征均是肺磨玻璃结节发生浸润性腺癌的危险因素(P<0.05)。ROC曲线分析显示,胸膜牵拉征、大小对肺磨玻璃结节发生浸润性腺癌均具有一定准确性的诊断价值(AUC=0.689、0.727),联合预测的AUC为0.821,灵敏性76.5%,特异度90.9%,诊断价值较高。结论高分辨率CT影像特征诊断肺磨玻璃结节患者病理分型具有较好价值。Objective Exploring the correlation between pathological classification and high-resolution CT imaging features in patients with pulmonary ground glass nodules.Methods A retrospective study was conducted on the clinical data of 82 patients with pulmonary ground glass nodules admitted to our hospital from July 2020 to December 2023.According to pathological results,they were divided into 26 cases of pre invasive lesions and 56 cases of invasive lesions(22 cases of micro invasive adenocarcinoma and 34 cases of invasive adenocarcinoma).The differences in high-resolution CT imaging features between the groups were compared,and the value of high-resolution CT imaging features in diagnosing pre invasive lesions and invasive adenocarcinoma of pulmonary ground glass nodules was analyzed.Results There was no statistically significant difference in age,gender,density,vacuolar sign,and air bronchogram sign between the two groups(P>0.05),but the invasive lesion group had higher size,spiciness sign,lobulation sign,vascular bundle sign,and pleural traction sign than the pre invasive lesion group(P<0.05).Binary logistic regression analysis showed that size,spiciness sign,lobulation sign,vascular bundle sign,and pleural traction sign were all risk factors for invasive lesions in pulmonary ground glass nodules(P<0.05).ROC curve analysis showed that spiculation sign,lobulation sign,vascular bundle sign,pleural traction sign,and size all have certain diagnostic value for invasive lesions in pulmonary ground glass nodules(AUC=0.783,0.749,0.792,0.686,0.809).There was no statistically significant difference in density,vacuole sign,vascular bundle sign,and air bronchogram sign between the two groups(P>0.05),but the invasive adenocarcinoma group had higher size,spiciness sign,lobulation sign,and pleural traction sign than the minimally invasive adenocarcinoma group(P<0.05).Binary logistic regression analysis showed that size and pleural traction sign were both risk factors for invasive adenocarcinoma of pulmonary ground glass nodules(P<

关 键 词：肺磨玻璃结节 病理分型 高分辨率CT 影像特征 相关性 

分 类 号：R563[医药卫生—呼吸系统]