新诊断2型糖尿病患者骨骼肌质量指数与胰岛β细胞储备功能相关性的研究  

Correlation between skeletal muscle mass index and isletβcell reserve function in patients with newly diagnosed type 2 diabetes mellitus

作　　者：范亚蕾 白桂荣 丁冰倩 李昕笃 朱婷婷 贺娟 张晓娟[3] 谢晓敏[2] FAN Yalei;BAI Guirong;DING Bingqian(The Second Clinical Medical College,Ningria Medical University,Yinchuan 750004,China)

机构地区：[1]宁夏医科大学第二临床医学院,银川750004 [2]银川市第一人民医院内分泌科 [3]银川市第一人民医院体检中心 [4]宁夏医科大学公共卫生学院,银川750004

出　　处：《中国糖尿病杂志》2025年第3期200-204,共5页Chinese Journal of Diabetes

基　　金：宁夏自然科学基金资助项目(2022AAC03732);宁夏科技厅中央引导地方科技发展专项基金资助项目(201949);宁夏回族自治区重点研发计划(2024BEG02015)。

摘　　要：目的 探讨新诊断T2DM患者骨骼肌质量指数(ASMI)与胰岛β细胞储备功能的相关性。方法 选取2022年6月至2023年11月银川市第一人民医院内分泌科治疗的新诊断T2DM患者100例,根据ASMI分为T2DM合并肌少症(Sar,n=50)组和单纯T2DM(T2DM,n=50)组,另选取同期本院体检健康者50名为正常对照(NC)组。检测各组FC-P、肝肾功能、血脂等指标,Spearman相关分析ASMI与其他指标的相关性,多重线性回归和Logistic回归分析ASMI、T2DM合并肌少症的影响因素。结果 T2DM、Sar组Hb A1c、FPG、TG水平高于NC组(P<0.05),FC-P、血肌酐(Scr)低于NC组(P<0.05)。Sar组FPG高于T2DM组(P<0.05),ASMI、FC-P、BMI低于T2DM组(P<0.05)。Spearman相关分析显示,ASMI与Hb A1c、FPG呈负相关(P<0.05),与BMI、ALT、Scr、SUA、FC-P呈正相关(P<0.05)。多重线性回归分析显示,BMI、Hb A1c、FC-P是ASMI影响因素(P<0.05)。Logistic回归分析显示,BMI、Hb A1c、FC-P是T2DM合并肌少症的影响因素(P<0.05)。结论ASMI可能与胰岛β细胞储备功能相关。Objective To investigate the correlation between skeletal muscle mass index(ASMI)and isletβcell reserve function in patients with newly diagnosed type 2 diabetes mellitus(T2DM).Methods A total of 100 patients with newly diagnosed T2DM were included in this study.All the patients were admited to the Department of Endocrinology in the First People's Hospital of Yinchuan between June 2022 and November 2023.They were divided into two groups according to their skeletal muscle mass index(ASMI):patients with T2DM accompanied by sarcopenia(Sar,n=50)group,and patients with simple T2DM(T2DM,n=50)group.Additionally,a control(NC)group consisting of 50 healthy participants was selected.Fasting C-peptide levels,liver and kidney function,blood lipid profiles,and other indicators were assessed in all the individuals.The correlation between ASMI and other indicators was analyzed,and the influencing factors for ASMI and T2DM combined with sarcopenia were analyzed respectively.R.esults The levels of HbAic,FPG,and TG were higher,while FC-P and Scr levels were lower in the T2DM group and Sar group compared with the NC group(P<0.05).FPG was higher,while ASMI,FC-P,BMI were lower in the Sar group than in the T2DM group(P<0.05).Spearman correlation analysis revealed a negative correlation between ASMI and FPG and HbAic(P<0.05),whereas a positive correlation was observed with BMI,ALT,Scr,SUA and FC-P(P<0.05).Multiple linear regression analysis indicated that BMI,HbAic and FC-P were influencing factors for ASMI(P<0.05).Furthermore,logistic regression analysis demonstrated that BMI,HbAic,FC-P were influencing factors for T2DM with sarcopenia(P<O.05).Conclusions The level of ASMI may be related to the reserve function of isletβcells.

关 键 词：糖尿病 2型 骨骼肌质量指数 空腹C肽 胰岛Β细胞 

分 类 号：R587.1[医药卫生—内分泌]