空腹血糖正常的成年男性甘油三酯-葡萄糖指数与高尿酸血症相关性的研究  

Correlation between triglyceride-glucose index and hyperuricemia in males with normal fasting blood glucose levels

作　　者：薛婧 魏晓伟 夏素影 肇炜博 史琳涛 施瑾怡 贾海英 杨月莹 杨笑 王爱红[1] XUE Jing;WEI Xiaowei;XIA Suying(Department of Endocrinology,Ninth Medical Center,PLA General Hospital,Beijing 100101,China)

机构地区：[1]解放军总医院第九医学中心内分泌科,北京100101

出　　处：《中国糖尿病杂志》2025年第3期205-209,共5页Chinese Journal of Diabetes

摘　　要：目的 探讨FPG正常的成年男性甘油三酯-葡萄糖(Ty G)指数与高尿酸血症(HUA)的相关性。方法 选取2024年4月于本中心参加健康体检FPG正常成年男性309名,根据血尿酸(SUA)水平分为正常SUA(NUA,n=218)组和高SUA(HUA,n=91)组,比较各组资料及生化指标差异。结果 HUA组体重、SBP、DBP、BMI、血肌酐(Scr)、TG、谷丙转氨酶(ALT)、谷草转氨酶(AST)、谷氨酰转肽酶(γ-GGT)、Ty G指数高于NUA组(P<0.05)。Pearson和Spearman相关分析显示,SUA与Scr、e GFR、TG、体重、SBP、DBP、BMI、ALT、AST、γ-GGT、Ty G指数呈正相关(P<0.05),与HDL-C呈负相关(P<0.05)。Logistic回归分析显示,校正混杂因素后,Ty G指数仍是HUA的影响因素。受试者工作特征曲线分析显示,Ty G指数预测HUA的曲线下面积为0.665,截断值为8.45。结论 Ty G指数是FPG正常成年男性HUA的影响因素,男性HUA与IR密切相关,是MS的重要组分。Objective To explore the correlation between triglyceride-glucose(TyG)index and hyperuricemia in men with normal fasting blood glucose(FPG)levels.Methods A total of 309 men with normal FPG who participated in a health examination at the Ninth Medical Center of the People's Liberation Army General Hospital in April 2024 were enrolled in this study.All the subjects were divided into the normal uric acid(NUA,n=218)group and the hyperuricemia(HUA,n=91)group according to serum uric acid(SUA)levels.Results Scr,TG,weight,SBP,DBP,BMI,ALT,AST,-GGT,and TyG index were higher in the HUA group than in the NUA group(P<0.05).Pearson and Spearman correlation analysis showed that SUA were positively correlated with Scr,eGFR,TG,weight,SBP,DBP,BMI,ALT,AST,-GGT and TyG(P<0.05),and negatively correlated with HDL-C(P<0.05).Logistic regression analysis showed that after adjusting for confounding factors,TyG index remained an important influencing factor for HUA.ROC curve analysis showed that the area under the ROC curve of TyG index predicting hyperuricemia in men with normal FPG was 0.665,with an cutoff value of 8.45.Conclusions TyG index in men with normal FPG are influencing factors for hyperuricemia,indicating that hyperuricemia has a close association with insulin resistance,and is an important component of metabolic syndrome.

关 键 词：高尿酸血症 甘油三酯-葡萄糖指数 男性 

分 类 号：R589.7[医药卫生—内分泌]