纤维蛋白原样蛋白1在代谢性疾病发病中作用的研究进展  

Research progress on the fibrinogen-like protein 1 in the pathogenesis of chronic metabolic diseases

作　　者：吴相杰 邓霞[1] 李昊翔 杨玲[1] WU Xiangjie;DENG Xia;LI Haoxiang(Department of Endocrinology and Metabolism,Affiliated Hospital of Jiangsu University,Zhenjiang 212001,China)

机构地区：[1]江苏大学附属医院内分泌代谢科,镇江212001

出　　处：《中国糖尿病杂志》2025年第3期237-240,共4页Chinese Journal of Diabetes

基　　金：镇江市重点研发计划(SH2023016)。

摘　　要：纤维蛋白原样蛋白1(FGL1)是新型肝因子,是纤维蛋白原家族的一员,其功能多样且复杂,参与多个生物学过程的调控。FGL1在代谢性疾病中具有重要的作用,但仍需要进一步研究其潜在机制和临床应用的可行性。本文综述FGL1在DM、肥胖症、代谢相关脂肪性肝病和多囊卵巢综合征发生发展中的作用。Fibrinogen-like protein 1(FGL1)is a novel hepatic factor and a member of the fibrinogen family.FGL1 has diverse and complex functions and is involved in the regulation of multiple biological processes.FGL1 has an important role in the study of metabolic diseases,but further studies are needed to reveal its underlying mechanisms and the feasibility of clinical applications.This review is to summarize the role of FGL1 in the development and progression of DM,obesity,metabolic associated fatty liver disease and polycystic ovarian syndrome.

关 键 词：纤维蛋白原样蛋白1 糖尿病 代谢性疾病 代谢相关脂肪性肝病 

分 类 号：R589[医药卫生—内分泌]