血糖间隙、中性粒细胞/淋巴细胞比值联合血脂对主要不良心血管事件的预测价值  

Prediction Value of Blood Glucose Gap,NLR Combined with Blood Lipid in Major Adverse Cardiovascular Events

作　　者：武丽娜[1] 梁海军[1] 颜文华[1] WU Li-na;LIANG Hai-jun;YAN Wen-hua(Department of Cardiology,The Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China)

机构地区：[1]郑州大学第五附属医院心血管内科,河南郑州450052

出　　处：《罕少疾病杂志》2025年第4期63-65,共3页Journal of Rare and Uncommon Diseases

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20220556)。

摘　　要：目的探讨血糖间隙、中性粒细胞计数/淋巴细胞计数(NLR)结合血脂这三个指标对诊断为急性冠脉综合征(ACS)的患者住院期间发生主要心血管不良事件(MACE)影响的临床研究。方法回顾性分析确诊ACS的患者235例,搜集临床资料及检验资料,根据其住院时出现MACE与否,分为事件组和非事件组,进行单因素及多因素逐步logistic回归分析ACS患者住院期间发生MACE的相关危险因素。利用受试者工作特征(ROC)曲线的曲线下面积(AUC)分析NLR、血糖间隙以及血脂对ACS患者住院期间发生MACE的预测价值。结果多因素logistic回归分析显示NLR、血糖间隙、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇是患者住院期间发生MACE的独立危险因素。四者联合预测MACE的敏感度和特异度均较高。结论血糖间隙、NLR、低密度脂蛋白胆固醇联合高密度脂蛋白胆固醇对ACS患者近期MACE发生的预测价值较高。Objective To investigate the effect of glycemic gap,neutrophil count/lymphocyte count(NLR)combined with blood lipid on major adverse cardiovascular events(MACE)during hospitalization in patients with acute coronary syndrome(ACS).Methods A retrospective analysis was performed on 235 patients diagnosed with ACS,clinical and laboratory data were collected.According to whether MACE occurred during hospitalization,the patients were divided into event group and non-event group,and the risk factors of MACE in patients with ACS during hospitalization were analyzed by one-way and multi-factor stepwise logistic regression.The area under the curve(AUC)of receiver operating characteristics(ROC)curve was used to analyze the predictive value of NLR,glycemic gap and blood lipid in the occurrence of MACE in patients with ACS.Results Multivariate logistic regression analysis showed that NLR,glycemic gap,low density lipoprotein cholesterol and high density lipoprotein cholesterol were independent risk factors for MACE during hospitalization.The sensitivity and specificity of the combined prediction of MACE were higher.Conclusion Glycemic gap,NLR,low density lipoprotein cholesterol combined with high density lipoprotein cholesterol had high predictive value for MACE occurrence in ACS patients.

关 键 词：血糖间隙 NLR 低密度脂蛋白胆固醇 高密度脂蛋白胆固醇 急性冠脉综合征 MACE 

分 类 号：R557.4[医药卫生—血液循环系统疾病]