血清血管生成素样蛋白3、中性粒细胞明胶酶相关载脂蛋白与老年冠心病冠脉病变狭窄程度的相关性分析  

Correlation Analysis between Serum ANGPTL3 and NGAL and the Degree of Coronary Lesion Stenosis in Elderly Patients with Coronary Heart Disease

作　　者：柴黎黎 王磊[1] CHAI Li-li;WANG Lei(General Internal Medicine Department,Henan Provincial Chest Hospital,Zhengzhou 450003,Henan Province,China)

机构地区：[1]河南省胸科医院普内科,河南郑州450003

出　　处：《罕少疾病杂志》2025年第4期75-77,共3页Journal of Rare and Uncommon Diseases

基　　金：河南省医学科技攻关计划项目(LHGJ20220223)。

摘　　要：目的分析血清学各项指标与老年冠心病患者冠脉病变狭窄程度之间的关系。方法选择2020年2月至2023年3月河南省胸科医院收治的108例老年冠心病患者,将其作为研究组,另选择同期因心前区不适入院,且经冠状动脉造影检查显示冠状动脉未见狭窄、排除冠心病的85例作为对照组,检测所有患者总胆固醇(TC)、三酰甘油(TG)、低密度蛋白胆固醇(LDL-C)、高密度蛋白胆固醇(HDL-C)、血清ANGPTL3、NGAL指标,采用冠状动脉造影评估冠状动脉狭窄程度,按照Gensini评分的高低将研究组患者分为低危组41例,中危组36例,高危组31例。将对照组、研究组患者血脂水平、血清ANGPTL3、NGAL水平,不同危险程度冠心病患者血清ANGPTL3、NGAL水平进行对比,采用Pearson软件分析血清ANGPTL3、NGAL水平与Gensini评分的相关性,分析老年冠心病患者冠脉病变狭窄程度的影响因素。结果研究组患者TC、TG、LDL-C、ANGPTL3、NGAL水平比对照组高,HDL-C水平比对照组低;高危组患者血清ANGPTL3、NGAL水平相较中危组升高,且中危组相较于低危组升高(均P<0.05);Pearson相关性分析显示,血清ANGPTL3、NGAL水平均与Gensini评分之间存在正相关关系(r=0.487、0.728,均P<0.05);影响老年冠心病患者冠脉病变狭窄程度的危险因素有年龄、吸烟、ANGPTL3、NGAL等(OR=1.822、1.733、1.507、1.664、1.716、2.113,均P<0.05)。结论老年冠心病患者血清ANGPTL3、NGAL水平异常升高,对上述两个指标进行检测可对老年冠心病患者冠脉病变狭窄程度予以预测,从而为临床冠心病的治疗提供参考与依据,临床可对上述危险因素采取相应的干预措施,以改善预后。Objective To analyze the relationship between various serological indexes and the degree of coronary artery lesion stenosis in elderly patients with coronary heart disease.Methods Select 108 elderly CAD patients admitted to Henan Chest Hospital from February 2020 to March 2023,Using it as a study group,In addition,admission due to discomfort in the same period.And coronary angiography showed no coronary artery stenosis,and 85 cases were excluded as the control group.All patients were tested for total cholesterol(TC),triacylglycerol(TG),low density protein cholesterol(LDL-C),high density protein cholesterol(HDL-C),serum ANGPTL3,NGAL indicators.The extent of the coronary artery stenosis was evaluated by coronary angiography,4 divided the patients in the low-risk group,of 36 patients in the intermediate-risk group.31 patients were included in the high-risk group.The serum lipid level,serum ANGPTL3 and NGAL level and serum ANGPTL3 and NGAL levels of patients with different risk levels of coronary heart disease were compared between control and study groups.The correlation between serum ANGPTL3 and NGAL levels and Gensini score was analyzed by Pearson software,and the influencing factors of the degree of coronary artery lesion stenosis in elderly patients with coronary heart disease were analyzed.Results Higher TC,TG,LDL-C,ANGPTL3,and NGAL than the control group,the HDL-C levels were lower than those in the control group;higher serum ANGPTL3 and NGAL levels in the high-risk group compared with the intermediate-risk group,moreover,the medium-risk group increased compared with the low-risk group(P<0.05);pearson Correlation analysis showed that,there was a positive correlation between serum ANGPTL3 and NGAL levels and Gensini score(r=0.487,0.728,all P<0.05);the risk factors influencing the degree of coronary lesion stenosis in elderly coronary patients were age,smoking,ANGPTL3,NGAL(OR=1.822,1.733,1.507,1.664,1.716,2.113,all cases:P<0.05).Conclusion The serum ANGPTL3 and NGAL levels in elderly patients with coronary heart

关 键 词：血管生成素样蛋白3 中性粒细胞明胶酶相关载脂蛋白 老年 冠心病 冠脉病变 狭窄程度 相关性 

分 类 号：R541.4[医药卫生—心血管疾病]