β2微球蛋白、视黄醇结合蛋白、尿微量白蛋白联合ACR对早期糖尿病肾病的诊断意义  

Diagnostic Significance ofβ2-MG,RBP,UAlb Combined with ACR in Early Diabetic Nephropathy

作　　者：王军 赵浩宇 WANG Jun;ZHAO Hao-yu(Department of laboratory,Zhengzhou Hospital of Traditional Chinese Medicine,Zhengzhou 450000,Henan Province,China)

机构地区：[1]郑州市中医院,河南郑州450000

出　　处：《罕少疾病杂志》2025年第4期90-92,共3页Journal of Rare and Uncommon Diseases

基　　金：2022年河南省医学科技攻关联合共建项目(LHGJ20210796)。

摘　　要：目的探讨β2微球蛋白(β2-MG)及视黄醇结合蛋白(RBP)、尿微量白蛋白(UAlb)、尿微量白蛋白/尿肌酐(ACR)在早期糖尿病肾病(DN)辅助诊断中的价值。方法选取2021年1月至2021年6月我院收治的102例DN患者为观察组,另选同期单纯糖尿病患者50例为对照组及健康体检者50例为健康组。均采集血液及尿液检测β2-MG、RBP及UAlb、ACR水平,比较三组间差异,并绘制ROC曲线分析β2-MG、RBP及UAlb、ACR及联合检测诊断DN的临床价值。结果观察组β2-MG、RBP及UAlb、ACR水平为(8.95±1.22)ng/mL、(12.83±1.32)mg/L、(201.86±42.25)mg/L、(42.84±4.42)mg/gCr,高于对照组[(5.12±1.03)ng/mL、(5.65±1.15)mg/L、(22.31±2.12)mg/L、(12.65±1.25)mg/gCr]、健康组[(4.42±0.63)ng/mL、(3.52±0.42)mg/L、(10.25±1.52)mg/L、(4.56±0.52)mg/gCr],有统计学差异(P<0.05);绘制ROC曲线显示,β2-MG、RBP、UAlb、ACR及联合检测诊断DN的曲线下面积分别为:0.717、0.770、0.756、0.814、0.972,联合检测诊断价值最高。结论β2-MG、RBP及UAlb、ACR在早期DN诊断中价值高,便于早期识别肾脏损伤,实现针对性治疗。Objective To investigate the value ofβ2 microglobulin(β2-mg),retinol binding protein(RBP),urinary microalbumin(UAlb)and urinary microalbumin/urinary creatinine(ACR)in the auxiliary diagnosis of early diabetic nephropathy(DN).Methods 102 patients with DN admitted to our hospital from January 2021 to June 2021 were selected as the observation group,50 patients with simple diabetes were selected as the control group and 50 healthy subjects were selected as the healthy group during the same period.Blood and urine were collected to detect the levels ofβ2-MG,RBP,UAlb and ACR,and the differences among the three groups were compared,and ROC curves were drawn to analyze the clinical value ofβ2-MG,RBP,UAlb,ACR and combined detection in the diagnosis of DN.Results The levels ofβ2-MG,RBP,UAlb and ACR in the observation group were(1.29±0.42)mg/L,(12.83±1.32)mg/L,(201.86±42.25)mg/L,(42.84±4.42)mg/gCr.It was higher than that of control group[(0.32±0.11)mg/L and(5.65±1.15)mg/L L,(22.31-2.12 mg/L),(12.65-1.25)mg/gCr],health group[(0.15-0.02 mg/L),(3.52-0.42 mg/L),(10.25-1.52 mg/L),(4.56-0.52)mg/gCr],There was statistical difference(P<0.05).The ROC curve showed that the area under the curve ofβ2-MG,RBP,UAlb,ACR and combined detection diagnosis DN were 0.717,0.770,0.756,0.814 and 0.972,respectively,and the combined detection had the highest diagnostic value.Conclusionβ2-MG,RBP,UAlb and ACR are of high value in the early diagnosis of DN,which is convenient for early identification of kidney injury and targeted treatment.

关 键 词：糖尿病肾病 Β2微球蛋白 视黄醇结合蛋白 尿微量白蛋白 诊断价值 

分 类 号：R587.2[医药卫生—内分泌]