卡前列素氨丁三醇联合马来酸麦角新碱对瘢痕子宫出血的预防效果  

The Preventive Effect of Carboprost Tromethamine Combined with Ergometrine Maleate on Scarred Uterine Bleeding

作　　者：谢淑红 XIE Shu-hong(Department of Obstetrics and Gynecology,Jiaozuo Second People's Hospital,Jiaozuo 454000,Henan Province,China)

机构地区：[1]焦作市第二人民医院妇产科,河南焦作454000

出　　处：《罕少疾病杂志》2025年第4期99-101,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的将卡前列素氨丁三醇联合马来酸麦角新碱用于瘢痕子宫剖宫产中,观察对产后出血的预防效果。方法取2019年9月至2023年9月期间,收治的300例瘢痕子宫合并妊娠患者且产前出血评分>4分产妇为研究对象,根据入院时间前后分组,对照组150例采取缩宫素联合麦角新碱,观察组150例采取卡前列素氨丁三醇联合马来酸麦角新碱,对两组出血情况及凝血纤溶功能进行比较。结果与对照组比较,观察组产后2h、24h出血量更低,产后恶露持续时间更短,PAI-1水平更低,子宫底下降速度更低,血红蛋白、红细胞计数、t-PA、vWF水平更高(P<0.05);观察组产后出血量发生率、子宫复旧不全发生率均较对照组低(P<0.05)。结论卡前列素氨丁三醇联合马来酸麦角新碱预防瘢痕子宫剖宫产产后出血的效果满意,能够有效减少产后出血量,预防产后出血发生,促进术后子宫修复,也可有效调节瘢痕子宫剖宫产产妇凝血纤溶功能。Objective To observe the preventive effect of carboprost tromethamine combined with ergometrine maleate on postpartum hemorrhage in cesarean section with scar uterus.Methods From September 2019 to September 2023,300 patients with scarred uterus complicated with pregnancy and a prenatal bleeding score greater than 4 were selected as the study subjects.They were divided into groups before and after admission.The control group(150 cases)received oxytocin combined with ergometrine,while the observation group(150 cases)received carboprost tromethamine combined with ergometrine maleate.Compare the bleeding situation and coagulation fibrinolysis function between two groups.Results Compared with the control group,the observation group had lower bleeding volume at 2 and 24 hours postpartum,shorter duration of postpartum lochia,lower PAI-1 levels,slower rate of uterine fundus descent,and higher levels of hemoglobin,red blood cell count,t-PA,and vWF(P<0.05).The incidence of postpartum hemorrhage and incomplete uterine involution in the observation group were lower than those in the control group(P<0.05).Conclusion The combination of carboprost tromethamine and ergoline maleate has shown satisfactory results in preventing postpartum hemorrhage in cesarean section with scarred uterus.It can effectively reduce the amount of postpartum hemorrhage,prevent postpartum hemorrhage,promote postoperative uterine repair,and regulate coagulation and fibrinolysis function in cesarean section with scarred uterus.

关 键 词：卡前列素氨丁三醇 马来酸麦角新 瘢痕子宫 剖宫产 产后出血 

分 类 号：R711.52[医药卫生—妇产科学]